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Comment
. 2021 Aug 9;39(8):1059-1061.
doi: 10.1016/j.ccell.2021.07.011.

The promise and peril of KRAS G12C inhibitors

Amanda R Moore  1 , Shiva Malek  2
Affiliations
Free article
Comment

The promise and peril of KRAS G12C inhibitors

Amanda R Moore et al. Cancer Cell. .
Free article

Abstract

RAS mutant tumors have been largely refractory to therapies until now. Recent findings published in the New England Journal of Medicine show that sotorasib provides clinical benefit for KRAS p.G12C-mutated non-small-cell lung cancer (NSCLC) and provide mechanistic insights into acquired resistance to KRASG12C-specific inhibition.

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Conflict of interest statement

Declaration of interests S.M. is an employee and stockholder of Genentech/Roche. A.R.M. is a post-doctoral fellow employed by Genentech/Roche.

Comment on

  • Acquired Resistance to KRASG12C Inhibition in Cancer.
    Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Jänne PA, Aguirre AJ. Awad MM, et al. N Engl J Med. 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. N Engl J Med. 2021. PMID: 34161704 Free PMC article.

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