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Comment
. 2021 Oct;29(10):869-870.
doi: 10.1016/j.tim.2021.07.005. Epub 2021 Aug 8.

CRISPR-Cas Toxin-Antitoxin Systems: Selfishness as a Constructive Evolutionary Force

Scott William Roy  1
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CRISPR-Cas Toxin-Antitoxin Systems: Selfishness as a Constructive Evolutionary Force

Scott William Roy. Trends Microbiol. 2021 Oct.

Abstract

A recent paper (Li et al.) reports a novel RNA-based Cas-dependent toxin-antitoxin system with the effect of 'addicting' cells to the cassette. Broadly-defined addiction systems could stabilize diverse genomic features, raising the question of the role of selfish elements and intragenomic conflict in the evolution of biological complexity.

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