Aneuploidy in the driving seat

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Comment

Dorothy Clyde. Nat Rev Genet. 2021 Oct.

. 2021 Oct;22(10):624-625.

doi: 10.1038/s41576-021-00411-2.

No abstract available

Comment on

Context is everything: aneuploidy in cancer.
Ben-David U, Amon A. Ben-David U, et al. Nat Rev Genet. 2020 Jan;21(1):44-62. doi: 10.1038/s41576-019-0171-x. Epub 2019 Sep 23. Nat Rev Genet. 2020. PMID: 31548659 Review.
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis.
Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ, Zhong J, Hsu PH, Paradis G, Ried T, Holland A, Van Deursen J, Amon A. Trakala M, et al. Genes Dev. 2021 Aug 1;35(15-16):1079-1092. doi: 10.1101/gad.348341.121. Epub 2021 Jul 15. Genes Dev. 2021. PMID: 34266888 Free PMC article.

1. Trakala, M. et al. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev. 35, 1079–1092 (2021) - DOI
1. Shoshani, O. et al. Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev. 35, 1093–1108 (2021) - DOI

1. Ben-David, U. & Amon, A. Context is everything: aneuploidy in cancer. Nat. Rev. Genet. 21, 44–62 (2020) - DOI