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Review
. 2021 Aug 3:14:959-969.
doi: 10.2147/CCID.S289716. eCollection 2021.

Current Clinical Options for the Management of Itch in Atopic Dermatitis

Zoe M Lipman  1 , Angelina Labib  1 , Gil Yosipovitch  1
Affiliations
Review

Current Clinical Options for the Management of Itch in Atopic Dermatitis

Zoe M Lipman et al. Clin Cosmet Investig Dermatol. .

Abstract

Pruritus is the most burdensome and prevalent symptom in patients suffering from atopic dermatitis. Treating atopic itch has historically been a challenge due to multiple underlying mechanisms within its pathogenesis and an incomplete understanding of them. In recent years, our understanding of these mechanisms have increased tremendously and subsequently, new treatments have reached the market that target the pathophysiology of atopic itch from different angles. In addition, there are several promising new treatments currently in development and trials. In the current article, we discuss these currently available treatment options, their available evidence and efficacy, and highlight some of the more recent advancements in the field.

Keywords: atopic dermatitis; eczema; itch; pruritus.

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Conflict of interest statement

Professor Gil Yosipovitch reports grants, personal fees from Pfizer, grants, personal fees from Sanofi Regeneron, grants, personal fees from Galderma, grants, personal fees from LEO, grants, personal fees from Novartis, grants, personal fees from Kiniksa, grants, personal fees from Bellus, personal fees from Eli Lilly, outside the submitted work. The authors declare that they have no other competing interests.

Figures

Figure 1
Figure 1
Therapeutic ladder for the treatment of itch in AD.
See this image and copyright information in PMC

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