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. 2021 Jul;25(3):e443-e445.
doi: 10.1055/s-0040-1715151. Epub 2020 Oct 15.

Tympanic Membrane Retractions in patients with Williams Syndrome: A Controlled Study

Marcelo Wierzynski Oliveira  1 , Joel Lavinsky  2   3 , Marcel Machado Valerio  4 , Temis Maria Felix  5 , Luiz Lavinsky  1
Affiliations

Tympanic Membrane Retractions in patients with Williams Syndrome: A Controlled Study

Marcelo Wierzynski Oliveira et al. Int Arch Otorhinolaryngol. 2021 Jul.

Abstract

Introduction The role of elastin in tympanic retractions and chronic otitis media is not well established. Williams Syndrome (WS), a pathology related to a mutation in the elastin gene, could generate tympanic retractions. Objective To compare the prevalence of tympanic retractions among patients with WS and controls. Methods WS patients ( n = 43 ears) and controls ( n = 130 ears) were evaluated by digital otoscopic examination and the degree of tympanic membrane retraction was classified by 2 blinded experienced otolaryngologists. Results The agreement rate between the evaluators was 71.1% for pars tensa and 65% for pars flaccida retraction ( p < 0.001). The pars tensa and pars flaccida retractions are present in patients with WS after an adjusted residue of respectively - 2.8 and - 2.6 ( p = 0.011 and p = 0.022) compared with controls. Conclusions Tympanic membrane retractions are not more common in the WS group when compared with controls.

Keywords: chronic otitis media; elastin; williams syndrome.

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References

    1. Ars B M. Tympanic membrane retraction pockets. Etiology, pathogeny, treatment. Acta Otorhinolaryngol Belg. 1991;45(03):265–277. - PubMed
    1. Yoon T H, Schachern P A, Paparella M M, Aeppli D M. Pathology and pathogenesis of tympanic membrane retraction. Am J Otolaryngol. 1990;11(01):10–17. - PubMed
    1. Tos M, Stangerup S E, Larsen P. Dynamics of eardrum changes following secretory otitis. A prospective study. Arch Otolaryngol Head Neck Surg. 1987;113(04):380–385. - PubMed
    1. Tos M. Upon the relationship between secretory otitis in childhood and chronic otitis and its sequelae in adults. J Laryngol Otol. 1981;95(10):1011–1022. - PubMed
    1. Ruah C B, Schachern P A, Zelterman D, Paparella M M, Yoon T H. Age-related morphologic changes in the human tympanic membrane. A light and electron microscopic study. Arch Otolaryngol Head Neck Surg. 1991;117(06):627–634. - PubMed