Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument

Affiliations

¹ Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada (R.T.).
² Center for Research on Health Care Data Center, Division of General Internal Medicine, University of Pittsburgh, PA (A.A.).
³ Renal-Electrolyte and Hypertension Division, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.B.C.).
⁴ Department of Cardiology, Princess Grace Hospital, Monaco (B.E.).
⁵ Department of Cardiology, University of Medicine and Pharmacy Victor Babeş Timişoara, Romania (B.E.).
⁶ Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH (J.B.H.).
⁷ Grant Family Medicine, OhioHealth, Columbus (M.J.).
⁸ Family Medicine Residency, AdventHealth Winter Park, FL (R.M.).
⁹ Western Sydney Local Health District, University of Wollongong, Australia (G.M.-K.).
¹⁰ Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles (B.Z.).
¹¹ Division of Cardiology, VA Greater Los Angeles Healthcare System, CA (B.Z.).
¹² Department of Medicine, University of Ottawa, ON, Canada (S.H.).

PMID: 34379435
PMCID: PMC8363122
DOI: 10.1161/HYPERTENSIONAHA.121.16501

Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument

Ricky D Turgeon et al. Hypertension. 2021 Sep.

. 2021 Sep;78(3):871-878.

doi: 10.1161/HYPERTENSIONAHA.121.16501. Epub 2021 Aug 11.

Authors

Affiliations

¹ Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada (R.T.).
² Center for Research on Health Care Data Center, Division of General Internal Medicine, University of Pittsburgh, PA (A.A.).
³ Renal-Electrolyte and Hypertension Division, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.B.C.).
⁴ Department of Cardiology, Princess Grace Hospital, Monaco (B.E.).
⁵ Department of Cardiology, University of Medicine and Pharmacy Victor Babeş Timişoara, Romania (B.E.).
⁶ Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH (J.B.H.).
⁷ Grant Family Medicine, OhioHealth, Columbus (M.J.).
⁸ Family Medicine Residency, AdventHealth Winter Park, FL (R.M.).
⁹ Western Sydney Local Health District, University of Wollongong, Australia (G.M.-K.).
¹⁰ Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles (B.Z.).
¹¹ Division of Cardiology, VA Greater Los Angeles Healthcare System, CA (B.Z.).
¹² Department of Medicine, University of Ottawa, ON, Canada (S.H.).

PMID: 34379435
PMCID: PMC8363122
DOI: 10.1161/HYPERTENSIONAHA.121.16501

No abstract available

Keywords: blood pressure; chronotherapy; circadian rhythm; clinical trial; epidemiology.

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Conflict of interest statement

Conflict(s) of Interest/Disclosure(s) Statement

None

Figures

**Figure 1:**
Proportion of days without drug intake by day of week for each category of takers: morning, evening, or variable, demonstrating lower adherence with evening intake compared to morning; from Vrijens et al, used with permission

See this image and copyright information in PMC

Comment in

Response to Lowering Nighttime Blood Pressure with Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Pro Side of the Argument.
Turgeon R, Althouse A, Cohen JB, Enache B, Hogenesch JB, Johansen M, Mehta R, Meyerowitz-Katz G, Ziaeian B, Hiremath S. Turgeon R, et al. Hypertension. 2021 Sep;78(3):893. Hypertension. 2021. PMID: 34483421 Free PMC article. No abstract available.

References

1. Kario K Nocturnal Hypertension: New Technology and Evidence. Hypertension (Dallas, Tex.: 1979) 2018;71(6):997–1009. - PubMed
1. Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, et al.Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. European Heart Journal 2020;41(48):4565–4576. - PubMed
1. Guthrie G, Poulter N, Macdonald T, Ford I, Mackenzie I, Findlay E, Williams B, Brown M, Lang C, Webb D. Chronotherapy in hypertension: the devil is in the details. European Heart Journal 2020;41(16):1606–1607. - PubMed
1. Anon. Relates to: “Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction: Hygia Chronotherapy Trial.” European Heart Journal 2020;41(16):1600. - PubMed
1. Anon. Relates to: “Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction: Hygia Chronotherapy Trial” byHermida Ramon C. et al.Eur Heart J 2020; 10.1093/eurheartj/ehz754.European Heart Journal 2020. - DOI - PubMed

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Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument

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Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument

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