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. 2021 Oct 20;73(8):1327-1329.
doi: 10.1093/cid/ciab677.

Severe Sepsis: The Fragile Anatomy of Crude Mortality

Nicole C Vissichelli  1 , Adam P Sima  2 , Richard P Wenzel  1
Affiliations

Severe Sepsis: The Fragile Anatomy of Crude Mortality

Nicole C Vissichelli et al. Clin Infect Dis. .

Abstract

Clinical trials of severe sepsis that target crude mortality are underpowered to detect mortality differences due to intervention. We discuss the importance of including subcomponents of crude mortality in study design; how the proportion of attributable mortality affects sample size requirements; and how minor changes from predicted outcomes affect interpretation.

Keywords: attributable mortality; clinical trial; crude mortality; sepsis.

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