Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)

Naoki Ohmiya¹, Shiro Oka², Yoshiko Nakayama³, Itaru Iwama⁴, Masanao Nakamura⁵, Hirotaka Shimizu⁶, Akihiko Sumioka², Naoki Abe⁷, Takahiro Kudo⁸, Satoshi Osawa⁹, Hitoshi Honma¹⁰, Takeru Okuhira¹¹, Shoji Mtsufuji¹², Hiroyuki Imaeda¹³, Kazuhiro Ota¹⁴, Ryo Matsuoka¹⁵, Naoki Hotta¹⁶, Mikihiro Inoue¹⁷, Konosuke Nakaji¹⁸, Hiroyuki Takamaru¹⁹, Keiji Ozeki²⁰, Taku Kobayashi²¹, Naoki Hosoe²², Hisao Tajiri²³, Shinji Tanaka²

Affiliations

¹ Departments of Gastroenterology and Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
² Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
³ Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
⁴ Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, Saitama, Japan.
⁵ Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
⁶ Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
⁷ Division of Infectious Diseases and Immunology, Aichi Children's Health and Medical Center, Aichi, Japan.
⁸ Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
⁹ Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
¹⁰ Department of Gastroenterology and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.
¹¹ Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.
¹² Department of Gastroenterology, Kyoto Kujo Hospital, Kyoto, Japan.
¹³ Department of Gastroenterology, Saitama Medical University, Saitama, Japan.
¹⁴ Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
¹⁵ Department of Pediatrics, Fuji City General Hospital, Shizuoka, Japan.
¹⁶ Department of Internal Medicine, Masuko Memorial Hospital, Aichi, Japan.
¹⁷ Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan.
¹⁸ Endoscopy Center, Aishinkai Nakae Hospital, Wakayama, Japan.
¹⁹ Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
²⁰ Departments of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
²¹ Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
²² Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan.
²³ Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.

PMID: 34379849
DOI: 10.1111/den.14104

Multicenter Study

Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)

Naoki Ohmiya et al. Dig Endosc. 2022 Mar.

. 2022 Mar;34(3):543-552.

doi: 10.1111/den.14104. Epub 2021 Sep 10.

Authors

Affiliations

¹ Departments of Gastroenterology and Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
² Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
³ Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
⁴ Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, Saitama, Japan.
⁵ Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
⁶ Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
⁷ Division of Infectious Diseases and Immunology, Aichi Children's Health and Medical Center, Aichi, Japan.
⁸ Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
⁹ Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
¹⁰ Department of Gastroenterology and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.
¹¹ Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.
¹² Department of Gastroenterology, Kyoto Kujo Hospital, Kyoto, Japan.
¹³ Department of Gastroenterology, Saitama Medical University, Saitama, Japan.
¹⁴ Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
¹⁵ Department of Pediatrics, Fuji City General Hospital, Shizuoka, Japan.
¹⁶ Department of Internal Medicine, Masuko Memorial Hospital, Aichi, Japan.
¹⁷ Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan.
¹⁸ Endoscopy Center, Aishinkai Nakae Hospital, Wakayama, Japan.
¹⁹ Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
²⁰ Departments of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
²¹ Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
²² Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan.
²³ Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.

PMID: 34379849
DOI: 10.1111/den.14104

Abstract

Background and aim: We retrospectively determined the safety and efficacy of the endoscopic delivery (ED) of capsule endoscopes.

Methods: We enrolled 10,156 patients who underwent small bowel capsule endoscopy (SBCE), 3182 who underwent patency capsule (PC), and 1367 who underwent colon capsule endoscopy (CCE), at 11 gastroenterological and nine pediatric centers.

Results: Small bowel capsule endoscopies, PCs, and CCEs were endoscopically delivered to 546 (5.4%), 214 (6.7%), and 14 (1.0%) patients, respectively. Only mild complications occurred for 21.6% (167/774), including uneventful mucosal damage, bleeding, and abdominal pain. Successful ED of SBCE to the duodenum or jejunum occurred in 91.8% and 90.7% of patients aged <16 years and ≥16 years, respectively (P = 0.6661), but the total enteroscopy rate was higher in the first group (91.7%) than in the second (76.2%, P < 0.0001), for whom impossible ingestion (87.3%) was significantly more common than prolonged lodging in the stomach (64.2%, P = 0.0010). Successful PC and CCE delivery to the duodenum occurred in 84.1% and 28.6%, thereafter the patency confirmation rate and total colonoscopy rate was 100% and 61.5%, respectively. The height, weight, and age cutoff points in predicting spontaneous ingestion were 132 cm, 24.8 kg, and 9 years 2 months, respectively, in patients aged <16 years. Patients aged ≥16 years could not swallow the SBCEs mainly due to dysphagia (75.0%); those who retained it in the esophagus due to cardiac disease (28.6%), etc. and in the stomach due to diabetes mellitus (15.7%), etc. CONCLUSIONS: This large-scale study supports the safety and efficacy of ED in adult and pediatric patients. UMIN000042020.

Keywords: AdvanCE; capsule endoscopy; net; pediatric endoscopy; snare.

PubMed Disclaimer

Comment in

Endoscopic delivery: A solution for capsule endoscopy in patients with swallowing disorders, difficulties, or impaired gastrointestinal motility.
Esaki M. Esaki M. Dig Endosc. 2022 Mar;34(3):472-473. doi: 10.1111/den.14242. Epub 2022 Feb 14. Dig Endosc. 2022. PMID: 35165931 No abstract available.
Capsule endoscopy in patients with surgically altered gastric anatomy: Oral ingestion should be preferred to endoscopic delivery.
Dray X, Koulaouzidis A. Dray X, et al. Dig Endosc. 2022 Jul;34(5):1074. doi: 10.1111/den.14325. Epub 2022 May 19. Dig Endosc. 2022. PMID: 35397128 No abstract available.
Response to reply to "Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)" by Ohmiya et al.
Ohmiya N. Ohmiya N. Dig Endosc. 2022 Jul;34(5):1075. doi: 10.1111/den.14347. Epub 2022 Jun 8. Dig Endosc. 2022. PMID: 35502934 No abstract available.

References

1. Iddan G, Meron G, Glukhovsky A et al. Wireless capsule endoscopy. Nature 2000; 405: 417.
1. Hollerbach S, Kraus K, Willert J et al. Endoscopically assisted video capsule endoscopy of the small bowel in patients with functional gastric outlet obstruction. Endoscopy 2003; 35: 226-9.
1. Carey EJ, Heigh RI, Fleischer DE. Endoscopic capsule endoscope delivery for patients with dysphagia, anatomical abnormalities, or gastroparesis. Gastrointest Endosc 2004; 59: 423-6.
1. Barth BA, Donovan K, Fox VL. Endoscopic placement of the capsule endoscope in children. Gastrointest Endosc 2004; 60: 818-21.
1. Holden JP, Dureja P, Pfau PR et al. Endoscopic placement of the small-bowel video capsule by using a capsule endoscope delivery device. Gastrointest Endosc 2007; 65: 842-7.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

The Japanese Association for Capsule Endoscopy

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)

Affiliations

Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)

Authors

Affiliations

Abstract

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources