Vitamin supplementation as a potential adjunctive therapeutic approach for COVID-19: biological and clinical plausibility
- PMID: 34380185
- DOI: 10.1515/jbcpp-2021-0111
Vitamin supplementation as a potential adjunctive therapeutic approach for COVID-19: biological and clinical plausibility
Abstract
The recent pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19) has introduced itself into the human population in the 21st century after the coronavirus diseases SARS-CoV and Middle East respiratory syndrome (MERS-CoV). Major investigations are underway worldwide in the search for pharmaceutical interventions for COVID-19 and many agents are administered in off-label routes. Several cases are under study to check or restrict clinical manifestations of COVID-19. According to the fact that the efficacy of some micro-nutrients like vitamins is proven to treat or prevent infectious diseases because of their antimicrobial and immunomodulatory activity, the potential role of vitamins in the COVID-19 treatment or prevention must be considered.
Keywords: COVID-19; immunomodulatory functions; prophylaxis; treatment; vitamins.
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
References
-
- James, PT, Ali, Z, Armitage, AE, Bonell, A, Cerami, C, Drakesmith, H, et al.. Could nutrition modulate COVID-19 susceptibility and severity of disease? A systematic review. medRxiv 2020. https://doi.org/10.1101/2020.10.19.20214395.
-
- Hemmat, N, Asadzadeh, Z, Ahangar, NK, Alemohammad, H, Najafzadeh, B, Derakhshani, A, et al.. The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV. Arch Virol 2021;166:675–96. https://doi.org/10.1007/s00705-021-04958-7.
-
- Abulmeaty, MMA, Aljuraiban, GS, Shaikh, SM, ALEid, NE, Mazrou, LRA, Turjoman, AA, et al.. The efficacy of antioxidant oral supplements on the progression of COVID-19 in non-critically ill patients: a randomized controlled trial. Antioxidants 2021;10. https://doi.org/10.3390/antiox10050804.
-
- Aghbash, PS, Eslami, N, Shirvaliloo, M, Baghi, HB. Viral coinfections in COVID-19. J Med Virol 2021. https://doi.org/10.1002/jmv.27102.
-
- Michos, ED, Cainzos-Achirica, M. Supplements for the treatment of mild COVID-19-challenging health beliefs with science from A to Z. JAMA Netw Open 2021;4:e210431. https://doi.org/10.1001/jamanetworkopen.2021.0431.
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