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. 2021 Sep;36(3):e2021019-0.
doi: 10.5620/eaht.2021019. Epub 2021 Aug 12.

Acute toxicity assessment for TiO2 photocatalyst (GST) made from wastewater using TiCl4 in rat

Ja Kyung Seol  1 , Myeongkyu Park  1 , Jae Min Im  1 , Heung Sik Seo  1 , Hee Ju Park  2 , Sung Soon Nah  3
Affiliations

Acute toxicity assessment for TiO2 photocatalyst (GST) made from wastewater using TiCl4 in rat

Ja Kyung Seol et al. Environ Anal Health Toxicol. 2021 Sep.

Abstract

TiO2 was a photocatalyst that used to the most common product because of the high efficiency. TiO2 (P-25, commercial nanomaterial product) is the most typical photocatalyst product and TiO2 (GST) was a sludge recycling product. This study was reported to evaluate an acute toxicity of TiO2 (P-25 and GST) according to OECD test guideline 402 and 423 in Sprague-Dawley (SD) female rats via route of oral and dermal. There was investigated the lethal dose (LD50), and mortality, clinical signs, body weight changes and gross findings were continually monitored for 14 days following the single administration. After administration, TiO2 (P-25) was calculated that LD50 was considered to be a dose of over 2000 mg/kg body weight for both different route of exposure, and TiO2 (GST) was the same. Other items were no observed an adverse effect between P-25 and GST; no mortality and clinical signs, accidental body weight loss, no gross findings. On the basis of the above results, the toxicity of the GST was almost equal to that of the commercial product, P-25 and there was no toxicological evidence.

Keywords: GST; P-25; TiO2; dermal; nanomaterial; oral.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Image of titanium dioxide (TiO2) GST by scanning electron microscope (SEM): (a) Morphology of the TiO2; (b) Primary particle size of the TiO2.
Figure 2
Figure 2
Zeta potential of TiO2 particles (GST); The value was negative zeta potential (−35.4 mV, 30 mg/mL).
Figure 3
Figure 3
Characterization of TiO2 particles (GST): (a) A particles dispersed in 99.9% EtOH was deposited on a copper grid and analyzed by TEM (Transmission electron microscope) image; (b) Size distribution of the imaged GST.
Figure 4
Figure 4
Body weight changes of titanium oxide (TiO2) GST: (a) Body weight of the 300 mg/kg body weight (1st step); (b) Body weight of the 300 mg/kg body weight (2nd step); (c) Body weight of the 2000 mg/kg body weight (3rd step); (d) Body weight of the 2000 mg/kg body weight (4th step).
Figure 5
Figure 5
Body weight changes of titanium oxide (TiO2) P-25: (a) Body weight of the 300 mg/kg body weight (1st step); (b) Body weight of the 300 mg/kg body weight (2nd step); (c) Body weight of the 2000 mg/kg body weight (3rd step); (d) Body weight of the 2000 mg/kg body weight (4th step).
Figure 6
Figure 6
Body weight changes of Titanium oxide (TiO2) GST: (a) Body weight of the Range-Finding study; (b) Body weight of the Main study.
Figure 7
Figure 7
Body weight changes of titanium oxide (TiO2) P-25: (a) Body weight of the range-finding study; (b) Body weight of the main study.
See this image and copyright information in PMC

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