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. 2021 Aug 11;21(1):459.
doi: 10.1186/s12877-021-02383-8.

Association between handgrip strength and cognition in a Chinese population with Alzheimer's disease and mild cognitive impairment

Hang Su  1 , Xiaokang Sun  1 , Fang Li  2 , Qihao Guo  3
Affiliations

Association between handgrip strength and cognition in a Chinese population with Alzheimer's disease and mild cognitive impairment

Hang Su et al. BMC Geriatr. .

Abstract

Background: This study aimed to explore the level and changes in handgrip strength among preclinical Alzheimer's disease (AD) and AD patients and to evaluate the association between handgrip strength and cognitive function.

Methods: A total of 1431 participants from the memory clinic of Shanghai JiaoTong University Affiliated Sixth People's Hospital and community were enrolled in the final analysis, including 596 AD, 288 mild cognitive impairment (MCI), and 547 normal individuals (NC). All participants received a comprehensive neuropsychological assessment. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment-Basic (MoCA-BC), and the Chinese version of Addenbrooke's Cognitive Examination III (ACE-III-CV) were used as cognitive tests. The receiver operating characteristic curve (ROC) was plotted to assess the power of handgrip strength as a screening measure to discriminate AD and MCI.

Results: The results showed that handgrip strength in the MCI group was significantly lower than that of NC group, and the AD group had a further decline (both P < 0.01). Multivariate logistic regression was performed with the handgrip strength quartiles, and the results showed that the ORs of AD for increasing levels of handgrip strength were 1.00, 0.58 (0.46-0.78), 0.51 (0.36-0.73), and 0.50 (0.35-0.68), showing a decreasing trend (Pfor trend < 0.01). The ROC curve demonstrated that the handgrip strength cutoff points for the identification of AD were 16.8 and 20.7 kg among the female participants above and under 70 yrs and 24.4 and 33.3 kg for the male participants above and under 70 yrs, respectively. Similarly, for the identification of MCI, cutoff points were 17.5 and 21.9 kg for females above 70 yrs and under 70 yrs, and 25.8 and 36.2 kg for males above 70 yrs and under 70 yrs, respectively.

Conclusions: Our study provided the further knowledge on the relationship between noncognitive features and cognition in populations with differing cognitive status, revealed that the stronger handgrip strength was associated with better performances on cognitive function. It can be speculated that handgrip strength can help early recognition of Chinese AD patients.

Keywords: Alzheimer's disease (AD); Handgrip strength; Mild cognitive impairment (MCI).

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Conflict of interest statement

Upon manuscript submission, all the authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Characteristics of handgrip strength levels in participates with different cognitive function. Abbreviation: AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal individuals
Fig. 2
Fig. 2
Sex-specific fitting curve of handgrip strength and MMSE scores. Abbreviation: MMSE, Mini-Mental State Examination
Fig. 3
Fig. 3
ROC curves for handgrip strength in the identification of AD (a. in the female above 70 yrs subgroup; b. in the female under 70 yrs subgroup; c. in the male above 70 yrs subgroup; d. in the male under 70 yrs subgroup) and MCI (e. in the female above 70 yrs subgroup; f. in the female under 70 yrs subgroup; g. in the male above 70 yrs subgroup; h. in the male under 70 yrs subgroup). Abbreviation: AD, Alzheimer's disease; MCI, mild cognitive impairment; ROC, receiver operating characteristic curve
See this image and copyright information in PMC

References

    1. Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer’s disease. Lancet. 2016;388(10043):505–517. doi: 10.1016/S0140-6736(15)01124-1. - DOI - PubMed
    1. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614–29. doi: 10.1016/S1474-4422(14)70090-0. - DOI - PubMed
    1. Reiman EM. Alzheimer’s disease and other dementias: advances in 2013. Lancet Neurol. 2014;13(1):3–5. doi: 10.1016/S1474-4422(13)70257-6. - DOI - PubMed
    1. Petersen RC. Alzheimer’s disease: progress in prediction. Lancet Neurol. 2010;9(1):4–5. doi: 10.1016/S1474-4422(09)70330-8. - DOI - PMC - PubMed
    1. Huang L, Chen K, Liu Z, Guo Q. A conceptual framework for research on cognitive impairment with no dementia in memory clinic. Curr Alzheimer Res. 2020;17(6):517–525. doi: 10.2174/1567205017666200807193253. - DOI - PubMed

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