Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;56(4):228-234.
doi: 10.1177/0018578719888913. Epub 2019 Nov 18.

Compatibility of Lactated Ringer's Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration

Margaux Vallée  1 , Isabelle Barthélémy  2 , Mihaela Friciu  3 , Élaine Pelletier  4 , Jean-Marc Forest  4 , France Benoit  5 , Grégoire Leclair  3
Affiliations

Compatibility of Lactated Ringer's Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration

Margaux Vallée et al. Hosp Pharm. 2021 Aug.

Abstract

Objective: To test the compatibility of intravenous (IV) lactated Ringer's injection (LR) with 94 injectable (IV) drugs during simulated Y-site administration. Methods: Ninety-four IV drugs were investigated for compatibility with LR (Baxter). Each sample was prepared in duplicate and performed at room temperature. Two observers performed visual evaluation independently immediately upon mixing and then 15 minutes, 1 hour, 2 hours, 3 hours, and 4 hours after admixture. Another observer performed a particle counting test on 1 of the 2 duplicates of each admixture that did not immediately show incompatibility and then after 4 hours by a light obscuration particle count test. Results: Of the 94 tested drugs, 86 were found to be compatible with LR. A total of 8 drugs were found to be physically incompatible. Of these incompatible drugs, 7 were directly identified visually and 1 was confirmed by the light obscuration particle count test. Conclusion: Lactated Ringer's injection was physically compatible for 4 hours with 86 tested drugs during simulated Y-site administration. Eight drugs, ciprofloxacin, cyclosporine, diazepam, ketamine, lorazepam, nitroglycerin, phenytoin, and propofol, were found to be incompatible and should not be administered with LR.

Keywords: Y-injection site; compatibility; lactated Ringer’s injection.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. National Center for Biotechnology Information (US). PubChem Compound Database; CID = 56841910 (Ringer’s lactate solution). Bethesda, MD: National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/56841910#section=Top. Accessed October 5, 2016.
    1. Sullivan T, Forest J-M, Leclair G. Compatibility of cloxacillin sodium with selected intravenous drugs during simulated Y-site administration. Hosp Pharm. 2015;50(3):214-220. - PMC - PubMed
    1. Ferreira E, Forest J-M, Hildgen P. Compatibilité du dimenhydrinate injectable pour l’administration en Y. Pharmactuel. 2004;37(1):17-20.
    1. Péré H, Chassé V, Forest J-M. Compatibilité du pantoprazole injectable lors d’administration en Y. Pharmactuel. 2004;37:193-196.
    1. Pelletier Forest ÉJ-M, Hildgen P. Compatibilité de la kétamine injectable lors de l’administration en dérivé avec d’autres médicaments usuels. Pharmactuel. 2006;39:71-75.

LinkOut - more resources