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Case Reports
. 2021 Jul 27:34:101487.
doi: 10.1016/j.rmcr.2021.101487. eCollection 2021.

Familial cluster of Inquilinus limosus infection among three brothers with cystic fibrosis

Watson L  1 , Andersson Mi  2 , Ives A  2 , Hull J  2 , Chapman Sj  2 , Flight Wg  2
Affiliations
Case Reports

Familial cluster of Inquilinus limosus infection among three brothers with cystic fibrosis

Watson L et al. Respir Med Case Rep. .

Abstract

Inquilinus limosus is an uncommon, poorly understood bacterium capable of infecting the respiratory tracts of people with cystic fibrosis. The transmission, clinical relevance and changes in antimicrobial resistance of I. limosus over time are unclear due to the low frequency of identification. We report three co-habiting brothers with cystic fibrosis who developed chronic I. limosus infection and document the clinical and microbiological features of the infections. Clinical evolution after Inquilinus infection varied but was associated with an initial decline in lung function. Familial clustering of this rare pathogen raises the possibility of cross-infection as a potential mechanism of transmission of Inquilinus between CF patients.

Keywords: Cross-infection; Cystic fibrosis; Inquilinus limosus; Respiratory infection.

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Conflict of interest statement

All authors declare no potential conflicts of interest related to the publication.

Figures

Fig. 1
Fig. 1
Pattern of positive Inquilinus isolates (A) and antimicrobial susceptibility profiles (B) in each sibling over time. In A, each vertical column reflects a 1 month period where ≥1 sibling produced a respiratory sample. Concordance between siblings is reflected by simultaneous Inquilinus-positive samples in ≥1 sibling in a given 1 month period.
See this image and copyright information in PMC

References

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