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. 2021 Jul 9;8(8):ofab370.
doi: 10.1093/ofid/ofab370. eCollection 2021 Aug.

Sex-Related Differences in Clinical Presentation and Risk Factors for Mortality in Patients Hospitalized With Coronavirus Disease 2019 in New York City

Jyoti S Mathad  1   2   3 , Myung Hee Lee  2 , Andrea Chalem  2 , Melissa K Frey  3 , Eloise Chapman-Davis  3 , Rohini V Kopparam  1 , Ashlesha K Dayal  3   4 , Gal Wald  1 , Laura C Pinheiro  1 , Michael J Satlin  1 , Parag Goyal  1 , Monika M Safford  1 , Mirella Salvatore  1 , Kevin Holcomb  3
Affiliations

Sex-Related Differences in Clinical Presentation and Risk Factors for Mortality in Patients Hospitalized With Coronavirus Disease 2019 in New York City

Jyoti S Mathad et al. Open Forum Infect Dis. .

Abstract

We evaluated sex-related differences in symptoms and risk factors for mortality in 4798 patients hospitalized with coronavirus disease 2019 in New York City. When adjusted for age and comorbidities, being male was an independent predictor of death with mortality significantly higher than females, even with low severe acute respiratory syndrome coronavirus 2 viral load at admission.

Keywords: COVID-19; mortality; risk factors; sex; viral load.

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Figures

Figure 1.
Figure 1.
Time to in-hospital death by severe acute respiratory syndrome coronavirus 2 viral load strata at admission in females and males. Kaplan-Meier curves (top): In females (left), viral load was inversely related to survival rate over time during hospitalization; females with a low viral load (green) had a significantly higher chance of survival compared to a medium (orange) or high (blue) viral load. In males (right), there was no significant difference in survival between males with a low or medium viral load. Males with a low or medium viral load had significantly higher survival compared to those with high viral load. Patients with a high viral load had the lowest chance of survival, regardless of sex. Table (bottom): Mortality was inversely related with viral load both in females and males. Among people with low viral loads, mortality was significantly higher in males vs females. Males and females had similar mortality in the medium and high groups.
See this image and copyright information in PMC

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