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Case Reports
. 2021 Jul 24:23:101180.
doi: 10.1016/j.ajoc.2021.101180. eCollection 2021 Sep.

Epiretinal membrane-induced intraretinal neovascularization

Ioannis Giachos  1 , Evangelia Chalkiadaki  1 , Konstantinos Andreanos  1 , Chrysanthos Symeonidis  1 , Alexandros Charonis  2 , Ilias Georgalas  1 , Tryfon Rotsos  1
Affiliations
Case Reports

Epiretinal membrane-induced intraretinal neovascularization

Ioannis Giachos et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To report a 71-year-old male patient diagnosed with epiretinal membrane-induced intraretinal neovascularization.

Observations: The presence of an epiretinal membrane (ERM) was confirmed by Optical Coherence Tomography (OCT), fluorescein and indocyanine angiography. Optical coherence tomography angiography (OCT-A) revealed a neovascular membrane within the ERM. Intravitreal ranibizumab injections were administered three times at four-week intervals. Imaging revealed a stable membrane with no leakage. Five months after the third injection, OCT revealed intraretinal fluid. OCT-A showed a new branch of the neo-vascular membrane at the superficial capillary plexus. Following an additional ranibizumab injection, the membrane stabilized.

Conclusions and importance: It is conceivable that neovascularization developed due to, or in close conjunction with an epiretinal membranes already in place.

Keywords: Epiretinal membrane; Intraretinal neovascularization; Optical coherence tomography; Optical coherence tomography angiography.

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Conflict of interest statement

The authors have no financial disclosures.

Figures

Fig. 1
Fig. 1
a. Fundoscopic view at presentation; Subhyaloid and intraretinal hemorrhage inferior to the foveola. b. Fluorescein angiography showing the intraretinal neovascular membrane, early arteriovenous phase, c. peak phase angiogram. d.-e. OCT scans of the right eye showing ERM and hyperreflective foci in the intraretinal edema in the macula.
Fig. 2
Fig. 2
Baseline visit. Deep capillary plexus, outer retina and choriocapillaris are depicted free of lesions.
Fig. 3
Fig. 3
OCT-Angiography: Neovascular membrane (a.) before the first injection, (b.) immediately after the first injection, (c.) one week after the first injection, (d.) one month after the first injection, (e.) one month after the second injection (f.) one month after the third injection.
Fig. 4
Fig. 4
a. Fundus photo of the right eye one month after the third intravitreal injection, (b.) OCT-Angiography of the lesion one month after the third intravitreal injection showing a vascular remnant configuration. c.and d. One and a half month after the fourth injection the membrane appears inactive and stable with one of its branches disappearing.
See this image and copyright information in PMC

References

    1. Pearlstone A.D. The incidence of idiopathic preretinal macular gliosis. Ann Ophthalmol. 1985;17:378–380. - PubMed
    1. Schmitz-Valckenberg S., Holz F.G., Bird A.C., Spaide A.F. Fundus autofluorescence imaging: Review and perspectives. Retina. 2008;28:385–409. - PubMed
    1. Kadonosono K., Itoh N., Nomura E., Ohno S. Capillary blood flow velocity in patients with idiopathic epiretinal membranes. Retina. 1999;19:536–539. - PubMed
    1. Wise G.N. Clinical features of idiopathic preretinal macular fibrosis. Schoenberg Lecture. Am J Ophthalmol. 1975;79:349–357. - PubMed
    1. Coscas G.J., Lupidi M., Coscas F., Cagini C., Souied E.H. Optical coherence tomography angiography versus traditional multimodal imaging in accessing the activity of exudative age-related macular degenaration: a new diagnostic challenge. Retina. 2015;35:2219–2228. - PubMed

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