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Review
. 2021 Sep;5(9):e2100663.
doi: 10.1002/adbi.202100663. Epub 2021 Aug 11.

Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease

Hariharan Murali Mahadevan  1 , Arsalan Hashemiaghdam  2 , Ghazaleh Ashrafi  2 , Angelika Bettina Harbauer  1   3   4
Affiliations
Review

Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease

Hariharan Murali Mahadevan et al. Adv Biol (Weinh). 2021 Sep.

Abstract

Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease.

Keywords: OXPHOS; glycolysis; neurodegeneration; synaptic transmission.

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