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. 2021 Aug 12;10(10):2.
doi: 10.1167/tvst.10.10.2.

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

Affiliations

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

Steven M Becker et al. Transl Vis Sci Technol. .

Abstract

Eight years since the launch of the National Eye Institute Audacious Goals Initiative for Regenerative Medicine, real progress has been made in the effort to restore vision by replacing retinal neurons. Although challenges remain, the infrastructure, tools, and preclinical models to support clinical studies in humans are being prepared. Building on the pioneering trials that are replacing the retinal pigment epithelium, it is expected that by the end of this decade first-in-human trials for the replacement of retinal neurons will be initiated.

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Conflict of interest statement

Disclosure: S.M. Becker, None; S.J. Tumminia, None; M.F. Chiang, None

References

    1. Luo YH, da Cruz L. The Argus II Retinal Prosthesis System. Prog Retin Eye Res .2016; 50: 89–107, [Pubmed]. - PubMed
    1. Maguire AM, Simonelli F, Pierce EA, et al. .. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med .2008; 358(21): 2240–2248, [Pubmed]. - DOI - PMC - PubMed
    1. Zarbin M, Sugino I, Townes-Anderson E. Concise review: update on retinal pigment epithelium transplantation for age-related macular degeneration. Stem Cells Transl Med. 2019; 8(5): 466–477, [Pubmed]. - PMC - PubMed
    1. Sharma R, Bose D, Maminishkis A, et al. .. Retinal pigment epithelium replacement therapy for age-related macular degeneration: are we there yet? Annu Rev Pharmacol Toxicol .2020; 60: 553–572, [Pubmed]. - PMC - PubMed
    1. Zakirova EY, Valeeva AN, Aimaletdinov AM, et al. .. Potential therapeutic application of mesenchymal stem cells in ophthalmology. Exp Eye Res. 2019; 189: 107863, [Pubmed]. - PubMed