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Review
. 2021 Sep 15;148(18):dev199778.
doi: 10.1242/dev.199778. Epub 2021 Aug 12.

In vivo live imaging of postnatal neural stem cells

Alina Marymonchyk  1   2 , Sarah Malvaut  1   2 , Armen Saghatelyan  1   2
Affiliations
Review

In vivo live imaging of postnatal neural stem cells

Alina Marymonchyk et al. Development. .

Abstract

Neural stem cells (NSCs) are maintained in specific regions of the postnatal brain and contribute to its structural and functional plasticity. However, the long-term renewal potential of NSCs and their mode of division remain elusive. The use of advanced in vivo live imaging approaches may expand our knowledge of NSC physiology and provide new information for cell replacement therapies. In this Review, we discuss the in vivo imaging methods used to study NSC dynamics and recent live-imaging results with respect to specific intracellular pathways that allow NSCs to integrate and decode different micro-environmental signals. Lastly, we discuss future directions that may provide answers to unresolved questions regarding NSC physiology.

Keywords: In vivo imaging; Adult neural stem cells; Mini-endoscopes; Mouse; Two-photon imaging; Zebrafish.

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Conflict of interest statement

Competing interests The authors declare no competing or financial interests.

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