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Review
. 2021 Oct:142:111998.
doi: 10.1016/j.biopha.2021.111998. Epub 2021 Aug 9.

The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule

Xuhui Shen  1 , Fugen Yin  2
Affiliations
Review

The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule

Xuhui Shen et al. Biomed Pharmacother. 2021 Oct.

Abstract

Lianhua-Qingwen capsule (LQC) is a commonly used Traditional Chinese Medicine (TCM) in China and has 11 herb components. The main active ingredient can target specific molecules and perform many clinic treatment roles. LQC has been authorized by National Medical Products Administration (NMPA) of China to treat severe acute respiratory syndrome (SARS) in 2002-2003, type A influenza virus HIN1 pandemic in 2009, H7N9, H3N2 and coronavirus disease-19 (COVID19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in 2020. It is also widely used to treat common cold with wind-heat syndrome, chronic rhinosinusitis (CRS), amygdalitis and chronic obstructive pulmonary disease. This article summarizes the advanced research progress of LQC in clinical application, mechanisms and provides new clues in the clinical application of LQC.

Keywords: Broad-spectrum antiviral; Lianhua-Qingwen capsule; SARS; SARS-COV-2.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pathogenesis of SARS-COV-2. S protein of SARS-COV-2 bind to ACE2 and endocytosed by target cells. In target cells, SARS-COV-2 replicated, assembled and released by exocytosis. Besides, SARS-COV-2 can downregulate ACE2 and make angiotensinⅡ bind to AT1R which induce NFκB pathway to regulate expression of DNA of inflammatory cytokines. SARS-COV-2 also can be recognized by IgG and induce immune cells to secrete cytokines. Finally, cytokines storm occurs and induce tissue injury.
Fig. 2
Fig. 2
Mechanism of Lianhuaqingwen capsule (LQC). LQC can inhibit M protein of SARS-COV-2 which help virus replication. LQC also inhibit binding of S protein with ACE2 and activation of cytokines. By blocking virus binding with cells, LQC prevent cytokines storm from occurring and protect the tissue.
See this image and copyright information in PMC

References

    1. Yi X. The antiviral report of Lianhua Qingwen capsule. Chin. Health Care. 2012;(9):13–14.
    1. Liu S.H., Chuang W.C., Lam W., Jiang Z., Cheng Y.C. Safety surveillance of traditional Chinese medicine: current and future. Drug Saf. 2015;38(2):117–218. - PMC - PubMed
    1. Duan Z.P., Jia Z.H., Zhang J., Liu S., Chen Y., Liang L.C., Zhang C.Q., Zhang Z., Sun Y., Zhang S.Q., Wang Y.Y., Wu Y.L. Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial. Chin. Med. J. 2011;124(18):2925–2933. - PubMed
    1. Liu C.Y., Li X.Q., Cai S.Q. Research progress on the pharmacological and clinical study of Lianhua Qingwen capsule. Chin. Med. Pharmacol. Clin. 2010;26(06):84–85.
    1. Wang C.H., Zhong Y., Zhang Y., Liu J.P., Wang Y.F., Jia W.N., Wang G.C., Li Z., Zhu Y., Gao X.M. A network analysis of the Chinese medicine Lianhua-Qingwen formula to identify its main effective components. Mol. Biosyst. 2016;12(2):606–613. - PubMed