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Published Erratum
. 2021 Sep 1;41(35):7509-7510.
doi: 10.1523/JNEUROSCI.1370-21.2021. Epub 2021 Aug 12.

Erratum: Kieran et al., "Control of Motoneuron Survival by Angiogenin"

No authors listed
Published Erratum

Erratum: Kieran et al., "Control of Motoneuron Survival by Angiogenin"

No authors listed. J Neurosci. .
No abstract available

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Figures

Figure 2.
Figure 2.
Lack of activity of the ALS-associated ANG mutants and potentiation of stress-induced cell injury by ANG knockdown. A, Western blot (two top panels) and quantitative real-time PCR analysis (two bottom panels) showing human ANG levels in NSC-34 cells transiently transfected with pIRES-DsRed2 constructs alone, or containing either ANG or K40I mutant ANG. B, NSC34 cells transiently transfected with pIRES-DsRed2/ANG are more resistant to tunicamycin-induced ER stress (500 nm, 24 h) than cells transfected with K40I ANG or with empty vector. Apoptotic cell death was assessed after Hoechst 33258 staining (*p < 0.01 vs treated empty vector, mean ± SEM, n = 7–10). C, Wild-type recombinant angiogenin protein protects NSC34 cells from serum deprivation-induced toxicity (24 h), while mutant K40I angiogenin protein shows no protective effect (*p < 0.01, mean ± SEM, n = 7–10). D, Wild-type angiogenin protein, but not K40I mutant angiogenin protein, elevated the levels of pAkt-1 in NSC34 cells during trophic factor withdrawal. NSC34 cells were subjected to serum deprivation for 2 h, and treated with vehicle, wild-type or mutant angiogenin protein (100 ng/ml), or fibroblast growth factor-2 (FGF-2; 100 ng/ml, 10 min; included as a positive control).
See this image and copyright information in PMC

Erratum for

  • Control of motoneuron survival by angiogenin.
    Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JH. Kieran D, et al. J Neurosci. 2008 Dec 24;28(52):14056-61. doi: 10.1523/JNEUROSCI.3399-08.2008. J Neurosci. 2008. PMID: 19109488 Free PMC article.

References

    1. Kieran D, Woods I, Villunger A, Strasser A, Prehn JH (2007) Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A 104:20606–20611. 10.1073/pnas.0707906105 - DOI - PMC - PubMed

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