Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
- PMID: 34385600
- PMCID: PMC8359627
- DOI: 10.1038/s41380-021-01254-3
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
Conflict of interest statement
NH, MS-R, EG, JK, AC, and FL are inventors on a patent application related to methods of treating COVID-19, filled by Assistance Publique —Hopitaux de Paris in France. NH has received personal fees and nonfinancial support from Lundbeck, outside the submitted work. AMR and EJL are inventors on a patent application related to methods of treating COVID-19, which was filed by Washington University in St. Louis. EJL has received consulting fees from Johnson and Johnson, and Jazz Pharmaceuticals. AMR has received grant or research support from the McDonnell Center for Systems Neuroscience, the McDonnell Center for Cellular and Molecular Neurobiology, and the Taylor Family Institute for Innovative Psychiatric Research. DS is the Chief Medical Officer and CEO of Enable Biosciences, a CLIA certified Federal clinical reference laboratory that performs COVID-19 antibody testing. CL reports personal fees and nonfinancial support from Janssen-Cilag, Lundbeck, Otsuka Pharmaceutical, and Boehringer Ingelheim, outside the submitted work. FL has received speaker and consulting fees from Janssen-Cilag, Euthérapie-Servier, and Lundbeck, outside the submitted work. Other authors declare no competing interests related to this work.
Comment on
-
Can antidepressants unlock prescription of rimonabant in the fight against COVID-19?Mol Psychiatry. 2021 Dec;26(12):7091-7092. doi: 10.1038/s41380-021-01221-y. Epub 2021 Jul 19. Mol Psychiatry. 2021. PMID: 34282263 Free PMC article. No abstract available.
-
Diversity of mechanism of action of psychotropic drugs in their anti-COVID-19 properties.Mol Psychiatry. 2021 Dec;26(12):7093-7097. doi: 10.1038/s41380-021-01222-x. Epub 2021 Jul 19. Mol Psychiatry. 2021. PMID: 34282264 Free PMC article. No abstract available.
References
-
- Hoertel N, Sánchez-Rico M, Vernet R, Beeker N, Jannot A-S, Neuraz A, et al. Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study. Mol Psychiatry. 2021. 10.1038/s41380-021-01021-4 Epub ahead of print. - PubMed
-
- Hoertel N, Sánchez-Rico M, Vernet R, Beeker N, Jannot A-S, Neuraz A, et al. SSRIs and SNRIs and Risk of Death or Intubation in COVID-19: Results from an Observational Study. medRxiv 2020.07.09.20143339; 10.1101/2020.07.09.20143339.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical