Corrigendum: Genome-Wide Variants Associated With Longitudinal Survival Outcomes Among Individuals With Coronary Artery Disease

Abstract

[This corrects the article DOI: 10.3389/fgene.2021.661497.].

Keywords: age-related disease; candidate gene analyses; coronary artery disease; genome-wide association study; survival analysis.

Figure 1

Study design and sample schema. This figure depicts the primary study (dark gray box) and extant sub-study data (light gray boxes) from which our retrospective datasets for the present analyses were derived (white boxes). The CATHGEN Biorepository containing data from 10,000 individuals recruited after cardiac catheterization (dark gray box) supplied the samples for two separate GWASs of CAD sub-studies (light gray boxes), providing the extant GWAS genotype data for our secondary analysis. The first GWAS sub-study contained data from a sequential sample of 2,203 CATHGEN CAD cases and controls (light gray box, left); the other CAD GWAS sub-study had data from 1,490 CATHGEN CAD cases and matched controls (light gray box, right). The white boxes display the secondary datasets we analyzed in the present retrospective study. Specifically, we derived our discovery cohort of 684 White CAD cases (white box, left) from the sequential case-control GWAS data; this discovery dataset was analyzed for Step 1. Our replication cohort of 404 White CAD cases (white box, right) was derived from the matched case-control GWAS dataset; this replication dataset was analyzed for Step 2. We then performed meta-analyses of our discovery and replication cohorts (black arrows converging on the bottom white box) for Step 3.