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. 2022 Jan;38(1):257-267.
doi: 10.1007/s10554-021-02374-1. Epub 2021 Aug 13.

Clinical experience with regadenoson SPECT myocardial perfusion imaging: insights into patient characteristics, safety, and impact of results on clinical management

Karthikeyan Ananthasubramaniam  1 , Matthew Saval  2 , Meredith Van Harn  3 , Therese M Kitt  4 , Rita M Kristy  4 , Yanqing Xu  4 , James R Spalding  4
Affiliations

Clinical experience with regadenoson SPECT myocardial perfusion imaging: insights into patient characteristics, safety, and impact of results on clinical management

Karthikeyan Ananthasubramaniam et al. Int J Cardiovasc Imaging. 2022 Jan.

Abstract

The Henry Ford Hospital (HFH) regadenoson (REG) registry includes patients with a variety of comorbidities allowing for the evaluation of outcomes in a large, unselected population. Using a database of electronic medical records and nuclear cardiology reports, patients aged > 18 years who underwent REG-facilitated single-photon emission computed tomography (SPECT) testing at HFH between January 2009 and August 2012 were identified. The primary objective was to describe the clinical and demographic characteristics of patients who had undergone REG only vs REG WALK (REG + low-level exercise) SPECT. A total of 2104 patients were included in the analysis (mean age 65.3 years; 50% women; 51% African American, 43% Caucasian). For the REG only (n = 1318) and REG WALK (n = 786) cohorts, SPECT was abnormal in 37% of patients (REG only, 39%; REG WALK, 34%; P < 0.01). No differences in diagnostic modalities or interventions in 90 days after SPECT were observed. Immediate safety analysis showed no deaths 48 h after REG SPECT testing. Although they guide invasive therapy, abnormal scans do not automatically lead to invasive testing. This demonstrates the focus on initial medical management, which reflects the existing evidence of initial goal-directed medical management of stable coronary disease.

Keywords: Coronary artery disease; Pharmacological stress agent; Regadenoson; Single-photon emission computed tomography; Stress testing outcomes.

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