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Review
. 2021 Oct;36(7):1591-1626.
doi: 10.1007/s11011-021-00806-4. Epub 2021 Aug 13.

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

Awanish Mishra  1   2 , Ritam Bandopadhyay  3 , Prabhakar Kumar Singh  3 , Pragya Shakti Mishra  4 , Neha Sharma  3 , Navneet Khurana  3
Affiliations
Review

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

Awanish Mishra et al. Metab Brain Dis. 2021 Oct.

Abstract

Neuroinflammation is one of the host defensive mechanisms through which the nervous system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation occurs as one of the most common pathological outcomes in various neurological disorders, makes it the promising target. The present review focuses on elaborating the recent advancement in understanding molecular mechanisms of neuroinflammation and its role in the etiopathogenesis of various neurological disorders, especially Alzheimer's disease (AD), Parkinson's disease (PD), and Epilepsy. Furthermore, the current status of anti-inflammatory agents in neurological diseases has been summarized in light of different preclinical and clinical studies. Finally, possible limitations and future directions for the effective use of anti-inflammatory agents in neurological disorders have been discussed.

Keywords: Alzheimer’s disease; Epilepsy; Neuroinflammation; Neurological disorders; Parkinson’s disease.

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