Recurrence of pulmonary embolism during anticoagulant treatment: a prospective study
- PMID: 3438891
- PMCID: PMC460799
- DOI: 10.1136/thx.42.7.481
Recurrence of pulmonary embolism during anticoagulant treatment: a prospective study
Abstract
The risk of early recurrence of pulmonary embolism in patients with venous thromboembolic disease treated by anticoagulants is not well established. To determine the risk linked to contemporary proximal deep venous thrombosis, a prospective study was organised to give clinical and scintigraphic surveillance to 50 patients with angiographically proved pulmonary embolism plus phlebographically proved proximal deep vein thrombosis during the first 15 days of anticoagulant treatment. Perfusion lung scans were performed initially and on days 3, 7, and 15. Only two patients had a recurrence of pulmonary embolism during this period; both episodes were revealed by new symptoms, and one recurrence was fatal. The systematic performance of angiography in four patients found to have new scintigraphic defects led to the diagnosis of "spurious scintigraphic recurrence" in three of them. It is concluded that (a) adjusted anticoagulant treatment showed an effectiveness of 96% for preventing early recurrence of pulmonary embolism in this group of supposed high risk patients, and (b) in patients with recent pulmonary embolism new defects on systematic perfusion lung scans are not specific indicators of recurrent pulmonary embolism.
Similar articles
-
Diagnosis of pulmonary embolism in patients with proximal deep vein thrombosis: specificity of symptoms and perfusion defects at baseline and during anticoagulant therapy.Am J Respir Crit Care Med. 2001 Sep 15;164(6):1033-7. doi: 10.1164/ajrccm.164.6.2101045. Am J Respir Crit Care Med. 2001. PMID: 11587992 Clinical Trial.
-
Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial.BMJ. 2007 Mar 31;334(7595):674. doi: 10.1136/bmj.39098.583356.55. Epub 2007 Feb 8. BMJ. 2007. PMID: 17289685 Free PMC article. Clinical Trial.
-
Prospective study on the usefulness of lung scan in patients with deep vein thrombosis of the lower limbs.Thromb Haemost. 2001 May;85(5):771-4. Thromb Haemost. 2001. PMID: 11372666 Clinical Trial.
-
Assessment of IVC filter efficacy in prevention of pulmonary thrombo-embolism by 99mTc-MAA lung perfusion scintigraphy--a case series and review of literature.Int J Cardiol. 2009 Mar 20;133(1):122-5. doi: 10.1016/j.ijcard.2007.08.120. Epub 2008 Jan 4. Int J Cardiol. 2009. PMID: 18180058 Review.
-
Acute pulmonary embolism.Dis Mon. 1994 Sep;40(9):467-523. Dis Mon. 1994. PMID: 8076500 Review.
Cited by
-
PHLECO: a multicenter study of the fate of 1647 hospital patients treated conservatively without fibrinolysis and surgery.Clin Investig. 1993 Jun;71(6):471-7. doi: 10.1007/BF00180062. Clin Investig. 1993. PMID: 8353407
-
Diagnosing pulmonary embolism.BMJ. 1992 May 2;304(6835):1126-7. doi: 10.1136/bmj.304.6835.1126. BMJ. 1992. PMID: 1392783 Free PMC article. No abstract available.
-
New anticoagulants: how to deal with treatment failure and bleeding complications.Br J Clin Pharmacol. 2011 Oct;72(4):593-603. doi: 10.1111/j.1365-2125.2011.04060.x. Br J Clin Pharmacol. 2011. PMID: 21752066 Free PMC article. Review.
-
Inhaled Nitric Oxide (iNO) With a Massive Pulmonary Embolism: A Case Report.Cureus. 2022 Jul 21;14(7):e27122. doi: 10.7759/cureus.27122. eCollection 2022 Jul. Cureus. 2022. PMID: 36004010 Free PMC article.
-
Massive Fatal Pulmonary Embolism While on Therapeutic Heparin Drip.J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620914787. doi: 10.1177/2324709620914787. J Investig Med High Impact Case Rep. 2020. PMID: 32208868 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical