. 2021 Aug;8(1):e000522.

doi: 10.1136/lupus-2021-000522.

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Kristina K Deonaraine¹, Philip M Carlucci¹, Andrea Fava², Jessica Li², David Wofsy³, Judith A James⁴, Chaim Putterman⁵, Betty Diamond⁶, Anne Davidson⁶, Derek M Fine⁷, Jose Monroy-Trujillo², Mohamed G Atta², Kristin Haag², Deepak A Rao⁸, William Apruzzese⁸, H Michael Belmont¹, Peter M Izmirly¹, Ming Wu⁹, Sean Connery¹⁰, Fernanda Payan-Schober¹⁰, Richard A Furie¹¹, Celine C Berthier¹², Maria Dall'Era³, Kerry Cho¹³, Diane L Kamen¹⁴, Kenneth Kalunian¹⁵, Jennifer Anolik¹⁶, Mariko Ishimori¹⁷, Michael H Weisman¹⁷; Accelerating Medicines Partnership RA/SLE network; Michelle A Petri¹⁸, Jill P Buyon¹⁹

Collaborators, Affiliations

Collaborators

Accelerating Medicines Partnership RA/SLE network:
Jennifer Goff, Patrick Dunn, Soumya Raychaudhuri, Fan Zhang, Ilya Korsunsky, Aparna Nathan, Joseph Mears, Kazuyoshi Ishigaki, Qian Xiao, Nghia Millard, Kathryn Weinand, Saori Sakaue, P J Utz, Rong Mao, Bill Robinson, Holden Maecker, Joel Guthridge, Wade DeJager, Susan Macwana, Louis Bridges, Vivian Bykerk, Laura Donlin, Susan Goodman, Edward DiCarlo, Melanie Smith, Amit Lakhanpal, Heather Sherman, Anvita Singaraju, Lorien Shakib, Christopher Ritchlin, Brendan Boyce, Darren Tabechian, Andrew McDavid, Javier Rangel-Moreno, Nida Meednu, Jen Albrecht, Michael Brenner, James Lederer, Kevin Wei, A Helena Jonsson, Daimon Simmons, Gregory Keras, Joshua Keegan, Gerald Watts, Yuhong Li, Zhu Zhu, Adam Chicoine, Zhihan Jian Li, Mandy McGeachy, Gary Firestein, David Boyle, Arnold Ceponis, Peter Gregersen, Diane Horowitz, Harris Perlman, Salina Dominguez, Carla Cuda, Arthur Mandelin, Anjali Thakrar, Joan Bathon, Laura Hughes, Mike Holers, Jennifer Seifert, Kevin Deane, Larry Moreland, Andrew Filer, Karim Raza, Ilfita Sahbudin, Constanino Pitzalis, Myles Lewis, Felice Rivellese, Alessandra Nerviani, Michele Bombardieri, Lindsy Forbess, Ami Ben-Artzi, Karen Salomon-Escoto, Ellen Gravallese, Jennifer Barnas, Arnon Arazi, Raymond Hsu, Robert Clancy, Beatrice Goilav, Steven Woodle, David Hildeman, Nir Hacohen, Paul Hoover, Thomas Eisenhaure, Michael Peters, Tony Jones, David Lieb, Thomas Tuschl, Hemant Suryawanshi, Manjunath Kustagi, Maureen McMahon, Jennifer Grossman, Matthias Kretzler, Jeffrey Hodgin, Raji Menon, Pavel Morozov

Affiliations

¹ Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA.
² Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
³ Rheumatology Division and Russell/Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, USA.
⁴ Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
⁵ Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
⁶ Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
⁷ Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA.
⁸ Division of Rheumatology, Inflammation, Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁹ Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
¹⁰ Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
¹¹ Division of Rheumatology, Northwell Health, Great Neck, NY, USA.
¹² Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA.
¹³ Nephrology Division, University of California San Francisco, San Francisco, CA, USA.
¹⁴ Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
¹⁵ University of California San Diego School of Medicine, La Jolla, CA, USA.
¹⁶ Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.
¹⁷ Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁸ Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA Jill.Buyon@nyulangone.org mpetri@jhmi.edu.
¹⁹ Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA Jill.Buyon@nyulangone.org mpetri@jhmi.edu.

PMID: 34389634
PMCID: PMC8354250
DOI: 10.1136/lupus-2021-000522

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Kristina K Deonaraine et al. Lupus Sci Med. 2021 Aug.

. 2021 Aug;8(1):e000522.

doi: 10.1136/lupus-2021-000522.

Authors

Collaborators

Accelerating Medicines Partnership RA/SLE network:
Jennifer Goff, Patrick Dunn, Soumya Raychaudhuri, Fan Zhang, Ilya Korsunsky, Aparna Nathan, Joseph Mears, Kazuyoshi Ishigaki, Qian Xiao, Nghia Millard, Kathryn Weinand, Saori Sakaue, P J Utz, Rong Mao, Bill Robinson, Holden Maecker, Joel Guthridge, Wade DeJager, Susan Macwana, Louis Bridges, Vivian Bykerk, Laura Donlin, Susan Goodman, Edward DiCarlo, Melanie Smith, Amit Lakhanpal, Heather Sherman, Anvita Singaraju, Lorien Shakib, Christopher Ritchlin, Brendan Boyce, Darren Tabechian, Andrew McDavid, Javier Rangel-Moreno, Nida Meednu, Jen Albrecht, Michael Brenner, James Lederer, Kevin Wei, A Helena Jonsson, Daimon Simmons, Gregory Keras, Joshua Keegan, Gerald Watts, Yuhong Li, Zhu Zhu, Adam Chicoine, Zhihan Jian Li, Mandy McGeachy, Gary Firestein, David Boyle, Arnold Ceponis, Peter Gregersen, Diane Horowitz, Harris Perlman, Salina Dominguez, Carla Cuda, Arthur Mandelin, Anjali Thakrar, Joan Bathon, Laura Hughes, Mike Holers, Jennifer Seifert, Kevin Deane, Larry Moreland, Andrew Filer, Karim Raza, Ilfita Sahbudin, Constanino Pitzalis, Myles Lewis, Felice Rivellese, Alessandra Nerviani, Michele Bombardieri, Lindsy Forbess, Ami Ben-Artzi, Karen Salomon-Escoto, Ellen Gravallese, Jennifer Barnas, Arnon Arazi, Raymond Hsu, Robert Clancy, Beatrice Goilav, Steven Woodle, David Hildeman, Nir Hacohen, Paul Hoover, Thomas Eisenhaure, Michael Peters, Tony Jones, David Lieb, Thomas Tuschl, Hemant Suryawanshi, Manjunath Kustagi, Maureen McMahon, Jennifer Grossman, Matthias Kretzler, Jeffrey Hodgin, Raji Menon, Pavel Morozov

Affiliations

¹ Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA.
² Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
³ Rheumatology Division and Russell/Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, USA.
⁴ Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
⁵ Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
⁶ Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
⁷ Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA.
⁸ Division of Rheumatology, Inflammation, Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁹ Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
¹⁰ Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
¹¹ Division of Rheumatology, Northwell Health, Great Neck, NY, USA.
¹² Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA.
¹³ Nephrology Division, University of California San Francisco, San Francisco, CA, USA.
¹⁴ Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
¹⁵ University of California San Diego School of Medicine, La Jolla, CA, USA.
¹⁶ Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.
¹⁷ Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁸ Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA Jill.Buyon@nyulangone.org mpetri@jhmi.edu.
¹⁹ Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA Jill.Buyon@nyulangone.org mpetri@jhmi.edu.

PMID: 34389634
PMCID: PMC8354250
DOI: 10.1136/lupus-2021-000522

Abstract

Objectives: In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.

Methods: 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.

Results: 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.

Conclusions: Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.

Keywords: autoimmunity; lupus erythematosus; lupus nephritis; systemic.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Flow diagram of adverse events (AEs) by relationship and seriousness.

See this image and copyright information in PMC

References

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Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Collaborators

Affiliations

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources