Comment

. 2021 Sep 18;398(10305):1038-1041.

doi: 10.1016/S0140-6736(21)01854-7. Epub 2021 Aug 13.

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Edward J Carr¹, Mary Wu¹, Ruth Harvey¹, Emma C Wall¹, Gavin Kelly¹, Saira Hussain¹, Michael Howell¹, George Kassiotis¹, Charles Swanton¹, Sonia Gandhi¹, David Lv Bauer¹; Haemodialysis COVID-19 consortium; Crick COVID Immunity Pipeline; Roseanne E Billany², Matthew Pm Graham-Brown², Joseph Beckett³, Katherine Bull⁴, Sushma Shankar⁵, Scott Henderson⁶, Reza Motallebzadeh⁷, Alan D Salama⁶, Lorraine Harper⁸, Patrick B Mark⁹, Stephen McAdoo¹⁰, Michelle Willicombe¹⁰, Rupert Beale¹¹

Collaborators, Affiliations

Collaborators

Sherna F Adenwalla, Paul Bird, Christopher Holmes, Katherine L Hull, Daniel S March, Haresh Selvaskandan, Jorge J Silva, Julian W Tang, Joanna Hester, Fadi Issa, Martin Barnardo, Peter J Friend, Andrew Davenport, Catriona Goodlad, Vignesh Gopalan, Theerasak Tangwonglert, Hans J Stauss, Alex G Richter, Adam F Cunningham, Marisol Perez-Toledo, Gemma D Banham, Nadya Wall, Candice L Clarke, Maria Prendecki, Bobbi Clayton, Sina Namjou, Vanessa Silva, Meghan Poulten, Philip Bawumia, Murad Miah, Samuel Sade, Mauro Miranda, Tom Taylor, Ilenia D'Angelo, Mercedes Cabrera Jarana, Mahbubur Rahman, Janet Abreu, Sandeep Sandhar, Neil Bailey, Simon Caidan, Marie Caulfield, Mary Wu, Ruth Harvey, Lorin Adams, Caitlin Kavanagh, Scott Warchal, Chelsea Sawyer, Mike Gavrielides, Jag Kandasamy, Karen Ambrose, Amy Strange, Titilayo Abiola, Nicola O'Reilly, Philip Hobson, Ana Agau-Doce, Emma Russell, Andrew Riddell, Svend Kjaer, Annabel Borg, Chloë Roustan

Affiliations

¹ The Francis Crick Institute, London NW1 1AT, UK.
² Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; Department of Renal Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
³ Transplantation Research & Immunology Group, University of Oxford, Oxford, UK.
⁴ Nuffield Department of Surgical Sciences and Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁵ Transplantation Research & Immunology Group, University of Oxford, Oxford, UK; Oxford Transplant Centre, University of Oxford, Oxford, UK.
⁶ UCL Department of Renal Medicine, Royal Free Hospital, London, UK.
⁷ UCL Department of Renal Medicine, Royal Free Hospital, London, UK; Research Department of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, London, UK.
⁸ Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Department of Nephrology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁹ Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
¹⁰ Centre for Inflammatory Disease, Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London UK; Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
¹¹ The Francis Crick Institute, London NW1 1AT, UK; UCL Department of Renal Medicine, Royal Free Hospital, London, UK. Electronic address: rupert.beale@crick.ac.uk.

PMID: 34391504
PMCID: PMC8360704
DOI: 10.1016/S0140-6736(21)01854-7

Comment

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Edward J Carr et al. Lancet. 2021.

. 2021 Sep 18;398(10305):1038-1041.

doi: 10.1016/S0140-6736(21)01854-7. Epub 2021 Aug 13.

Authors

Collaborators

Sherna F Adenwalla, Paul Bird, Christopher Holmes, Katherine L Hull, Daniel S March, Haresh Selvaskandan, Jorge J Silva, Julian W Tang, Joanna Hester, Fadi Issa, Martin Barnardo, Peter J Friend, Andrew Davenport, Catriona Goodlad, Vignesh Gopalan, Theerasak Tangwonglert, Hans J Stauss, Alex G Richter, Adam F Cunningham, Marisol Perez-Toledo, Gemma D Banham, Nadya Wall, Candice L Clarke, Maria Prendecki, Bobbi Clayton, Sina Namjou, Vanessa Silva, Meghan Poulten, Philip Bawumia, Murad Miah, Samuel Sade, Mauro Miranda, Tom Taylor, Ilenia D'Angelo, Mercedes Cabrera Jarana, Mahbubur Rahman, Janet Abreu, Sandeep Sandhar, Neil Bailey, Simon Caidan, Marie Caulfield, Mary Wu, Ruth Harvey, Lorin Adams, Caitlin Kavanagh, Scott Warchal, Chelsea Sawyer, Mike Gavrielides, Jag Kandasamy, Karen Ambrose, Amy Strange, Titilayo Abiola, Nicola O'Reilly, Philip Hobson, Ana Agau-Doce, Emma Russell, Andrew Riddell, Svend Kjaer, Annabel Borg, Chloë Roustan

Affiliations

¹ The Francis Crick Institute, London NW1 1AT, UK.
² Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; Department of Renal Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
³ Transplantation Research & Immunology Group, University of Oxford, Oxford, UK.
⁴ Nuffield Department of Surgical Sciences and Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁵ Transplantation Research & Immunology Group, University of Oxford, Oxford, UK; Oxford Transplant Centre, University of Oxford, Oxford, UK.
⁶ UCL Department of Renal Medicine, Royal Free Hospital, London, UK.
⁷ UCL Department of Renal Medicine, Royal Free Hospital, London, UK; Research Department of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, London, UK.
⁸ Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Department of Nephrology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁹ Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
¹⁰ Centre for Inflammatory Disease, Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London UK; Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
¹¹ The Francis Crick Institute, London NW1 1AT, UK; UCL Department of Renal Medicine, Royal Free Hospital, London, UK. Electronic address: rupert.beale@crick.ac.uk.

PMID: 34391504
PMCID: PMC8360704
DOI: 10.1016/S0140-6736(21)01854-7

Erratum in

Department of Error.
[No authors listed] [No authors listed] Lancet. 2021 Sep 18;398(10305):1042. doi: 10.1016/S0140-6736(21)01890-0. Epub 2021 Aug 17. Lancet. 2021. PMID: 34416197 Free PMC article. No abstract available.

No abstract available

PubMed Disclaimer

Conflict of interest statement

CS reports grants from BMS, Ono-Pharmaceuticals, BoehringerIngelheim, Roche-Ventana, Pfizer, and Archer Dx, unrelated to this Correspondence; personal fees from Genentech, Sarah Canon Research Institute, Medicxi, Bicycle Therapeutics, GRAIL, Amgen, AstraZeneca, BMS, Illumina, GlaxoSmithKline, MSD, and Roche-Ventana, unrelated to this Correspondence; and stock options from Apogen Biotech, Epic Biosciences, GRAIL, and Achilles Therapeutics, unrelated to this Correspondence. PBM reports personal fees and non-financial support from Vifor, Napp, Pharmacosmos, Astra Zeneca, Astellas, and Novartis; and grants from Boehringer Ingelheim. RB and DLVB are members of the Genotype-to-Phenotype UK National Virology Consortium. All other authors declare no competing interests. Funding details and acknowledgments can be found in the appendix. All data (anonymised) and full R code to produce figures and statistical analysis presented in this Correspondence are available online. Members of the Haemodialysis COVID-19 consortium and the Crick COVID Immunity Pipeline are listed in the appendix.

Figures

See this image and copyright information in PMC

Comment in

Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients.
Carr EJ, Wu M, Harvey R, Billany RE, Wall EC, Kelly G; Haemodialysis COVID-19 Consortium, Crick COVID Immunity Pipeline; Howell M, Kassiotis G, Swanton C, Gandhi S, Bauer DL, Graham-Brown MP, Jones RB, Smith RM, McAdoo S, Willicombe M, Beale R. Carr EJ, et al. Lancet. 2022 Feb 26;399(10327):800-802. doi: 10.1016/S0140-6736(22)00104-0. Epub 2022 Jan 20. Lancet. 2022. PMID: 35065703 Free PMC article. No abstract available.

Comment on

Review of Early Immune Response to SARS-CoV-2 Vaccination Among Patients With CKD.
Carr EJ, Kronbichler A, Graham-Brown M, Abra G, Argyropoulos C, Harper L, Lerma EV, Suri RS, Topf J, Willicombe M, Hiremath S. Carr EJ, et al. Kidney Int Rep. 2021 Sep;6(9):2292-2304. doi: 10.1016/j.ekir.2021.06.027. Epub 2021 Jul 6. Kidney Int Rep. 2021. PMID: 34250319 Free PMC article.

References

1. UK Renal Registry . The Renal Association; Bristol: 2020. UK Renal Registry (2020) COVID-19 surveillance report for renal centres in the UK: a summary of the first wave of the pandemic – March to August 2020.
1. Li KK, Woo YM, Stirrup O, et al. Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. J Infect. 2021;83:96–103. - PMC - PubMed
1. Public Health England . Public Health England; London: 2021. Immunisation against infectious disease: the Green Book.
1. Alcázar-Arroyo R, Portolés J, López-Sánchez P, et al. Rapid decline of anti-SARS-CoV-2 antibodies in patients on haemodialysis: the COVID-FRIAT study. Clin Kidney J. 2021;14:1835–1844. - PMC - PubMed
1. Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383:2603–2615. - PMC - PubMed

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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

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