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Review
. 2021 Nov;76(11):3390-3407.
doi: 10.1111/all.15054. Epub 2021 Aug 29.

Advances and highlights in asthma in 2021

Ioana Agache  1 , Ibon Eguiluz-Gracia  2 , Catalina Cojanu  1 , Alexandru Laculiceanu  1 , Stefano Del Giacco  3 , Magdalena Zemelka-Wiacek  4 , Anna Kosowska  4   5 , Cezmi A Akdis  6 , Marek Jutel  4   5
Affiliations
Free article
Review

Advances and highlights in asthma in 2021

Ioana Agache et al. Allergy. 2021 Nov.
Free article

Abstract

Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real-world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.

Keywords: asthma; biomarkers; endotypes; exacerbations; guidelines.

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References

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