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. 2021 Jul-Aug;25(4):313-319.
doi: 10.4103/jisp.jisp_440_20. Epub 2021 Jul 1.

Extracellular matrix containing nanocomposite bone graft in periodontal regeneration - A randomized controlled clinical and radiographic evaluation

Abhinav Prakash Deshpande  1 , Mala Dixit Baburaj  1 , Lashika Vasant Tambe  1 , Upendra Prasad  1
Affiliations

Extracellular matrix containing nanocomposite bone graft in periodontal regeneration - A randomized controlled clinical and radiographic evaluation

Abhinav Prakash Deshpande et al. J Indian Soc Periodontol. 2021 Jul-Aug.

Abstract

Background: The study aims to evaluate the effect of adding extracellular matrix (ECM) component - natural collagen to nanocrystalline hydroxyapatite (nHA) bone graft in the treatment of intrabony defect in chronic periodontitis patients.

Materials and methods: Forty chronic periodontitis patients having at least one intrabony defect were treated surgically by open flap debridement and the defect grafted (Group A: 20 sites grafted with nHA with natural collagen and Group B: 20 sites grafted with nHA). Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) were evaluated.

Results: The mean PPD reduced from 7.6 ± 0.88 at baseline to 4.45 ± 0.69 and 2.60 ± 0.6 at 3 and 6 months, respectively, in Group A. In Group B, the mean PPD reduced from 7.5 ± 0.89 at baseline to 4.95 ± 0.60 and 2.65 ± 0.59 at 3 and 6 months, respectively. The mean CAL reduced from 7.75 ± 0.85 at baseline to 5.05 ± 0.76 and 3.6 ± 0.68 at 3 and 6 months, respectively, in Group A. In Group B, the mean CAL reduced from 7.70 ± 0.86 at baseline to 5.8 ± 0.7 and 3.75 ± 0.64 at 3 and 6 months, respectively. The mean RDD reduced from 8.13 ± 0.78 and 8.12 ± 0.83 at baseline to 4.27 ± 0.66 and 3.94 ± 0.5 after 6 months in Groups A and B, respectively. After 3 months, a statistically significant reduction in mean PPD and CAL values was noted in Group A while the results were comparable after 6 months.

Conclusion: The effectiveness of nHA composite during initial healing phase (3 months) can be attributed to the presence of ECM-collagen in bone graft matrix.

Keywords: Bone grafts; collagen; extracellular matrix; nanocrystalline hydroxyapatite; periodontal regeneration.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Nanocrystalline hydroxyapatite bone graft – Sybograf, Eucare Pharmaceuticals Private Limited, Chennai, India; (b) Nanocrystalline hydroxyapatite with natural collagen bone graft – Sybograf C, Eucare Pharmaceuticals Private Limited, Chennai, India
Figure 2
Figure 2
(a) Group A: Open flap debridement surgery – Presurgical vertical probing pocket depth; (b) Debridement of intraoral defect. (c) Placement of bone graft – Sybograf C, Eucare Pharmaceuticals Private Limited, Chennai, India, in intrabony defect; (d) Vertical probing depth after 3 months; (e) Vertical probing depth after 6 months
Figure 3
Figure 3
(a) Group B: Open flap debridement surgery – Presurgical vertical probing pocket depth; (b) Debridement of intraoral defect; (c) Placement of Bone Graft – Sybograf, Eucare Pharmaceuticals Private Limited, Chennai, India, in intrabony defect after presuturing; (d) Vertical probing depth after 3 months; (e) Vertical probing depth after 6 months
Figure 4
Figure 4
(a) Group A: Presurgical/baseline intraoral periapical radiograph; (b) Group A: Immediate postoperative intraoral periapical radiograph; (c) Group A: 6 months postsurgery intraoral periapical radiograph; (d) Group B: Presurgical/baseline intraoral periapical radiograph; (e) Group B: Immediate postoperative intraoral periapical radiograph; (f) Group B: 6 months postsurgery intraoral periapical radiograph
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