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Clinical Trial
. 2021 Aug 7:13:6191-6197.
doi: 10.2147/CMAR.S314310. eCollection 2021.

Psychosocial Burden and Quality of Life of Lung Cancer Patients: Results of the EORTC QLQ-C30/QLQ-LC29 Questionnaire and Hornheide Screening Instrument

Myriam Koch  1 , Laura Gräfenstein  2   3 , Julia Karnosky  4 , Christian Schulz  1 , Michael Koller  2
Affiliations
Clinical Trial

Psychosocial Burden and Quality of Life of Lung Cancer Patients: Results of the EORTC QLQ-C30/QLQ-LC29 Questionnaire and Hornheide Screening Instrument

Myriam Koch et al. Cancer Manag Res. .

Abstract

Background: Overall survival is the ultimate criterion for the therapy of lung cancer, but psychosocial care, which helps the patient to cope with the disease, becomes a more and more important issue in the treatment of this life-threatening disease.

Methods: We report the satellite project within a prospective, international, cross-cultural, multicenter study to validate the EORTC QLQ-LC29, a new designed module to assess the quality of life of lung cancer patients. The participants filled in the EORTC QLQ-C30, the recently updated lung cancer module QLQ-LC29 and the Hornheide questionnaire (HSI).

Results: A total of 81 patients (32 female and 49 male, mean age 65.2 years, SD = 9.7) were enrolled in this study by completing the questionnaires. Fatigue (mean 55.4, SD = 26.3) and dyspnea (mean 46.3, SD = 36.2) were the most prominent symptoms. Thirty-nine patients (48.1%) according to the HSI needed psychosocial support. When using the EORTC questionnaires as screening instrument with 50 as cut-off in contrast only 29.5% of our patients needed psychosocial support. The need for psychosocial support according to the HSI correlated most with the EORTC scales "fatigue" (38.3% overlap between the two questionnaires), "existential fear" (38.3% overlap between the two questionnaires) and worse "global quality of life" (27.2% overlap between the two questionnaires).

Conclusion: If psychosocial distress is at the core, the HSI is a suitable instrument for quick screening. The EORTC measures help to specify impaired quality of life areas and also cover somatic symptoms that are specific for cancer patients. Once psychosocial distress has been ascertained, clinicians should be particularly aware of specific problems regarding "fatigue", "existential fear" and diminished "global quality of life".

Trial registration: clinicaltrials.gov, reference number NCT02745691. Registered 20 April 2016.

Keywords: EORTC QLQ-C30/QLQ-LC29 questionnaire; Hornheide screening instrument; lung cancer; psychosocial burden; quality of life.

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Conflict of interest statement

Prof. Dr. Michael Koller reports a grant from EORTC to conduct the study (Reference number: Koller Lung 03/2016). The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Need for psychosocial help after Hornheide screening instrument in comparison with EORTC QLQ-C30/LC29 subscales.
See this image and copyright information in PMC

References

    1. Ulas A, Tokluoglu S, Kos M, et al. Lung cancer in women, a different disease: survival differences by sex in Turkey. Asian Pacific J Cancer Preven. 2015;16(2):815–822. - PubMed
    1. Kim HR, Kim SY, Kim CH, et al. Sex-specific incidence of EGFR mutation and its association with age and obesity in lung adenocarcinomas: a retrospective analysis. J Cancer Res Clin Oncol. 2017;143(11):2283–2290. doi:10.1007/s00432-017-2473-8 - DOI - PMC - PubMed
    1. Rauma V, Salo J, Sintonen H, Rasanen J, Ilonen I. Patient features predicting long-term survival and health-related quality of life after radical surgery for non-small cell lung cancer. Thoracic Cancer. 2016;7(3):333–339. doi:10.1111/1759-7714.12333 - DOI - PMC - PubMed
    1. van Montfort E, de Vries J, Arts R, Aerts JG, Kloover JS, Traa MJ. The relation between psychological profiles and quality of life in patients with lung cancer. Support Care Cancer. 2019;28(3):1359–1367. - PMC - PubMed
    1. Velikova G, Booth L, Smith AB, et al. Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol. 2004;22(4):714–724. doi:10.1200/JCO.2004.06.078 - DOI - PubMed

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