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Meta-Analysis
. 2021 Mar;21(1):1-7.
doi: 10.4314/ahs.v21i1.2.

The efficacy of dapagliflozin for type 1 diabetes: a meta-analysis of randomized controlled studies

Jian Ma  1 , Yanhong Zhao  1 , Huihui Fan  1 , Jia Liu  2
Affiliations
Meta-Analysis

The efficacy of dapagliflozin for type 1 diabetes: a meta-analysis of randomized controlled studies

Jian Ma et al. Afr Health Sci. 2021 Mar.

Abstract

Introduction: The efficacy of dapagliflozin for type 1 diabetes remains controversial. We conduct a systematic review and meta-analysis to explore the treatment efficacy of dapagliflozin versus placebo in patients with type 1 diabetes.

Methods: We have searched PubMed, EMbase, Web of science, EBSCO and Cochrane library databases through May 2019 for randomized controlled trials (RCTs) assessing the effect of dapagliflozin versus placebo for type 1 diabetes. This meta-analysis is performed using the random-effect model.

Results: Six RCTs are included in the meta-analysis. Overall, compared with control group for type 1 diabetes, dapagliflozin treatment shows favorable impact on glycated hemoglobin HbA1c (standard mean difference SMD=-3.93; 95% confidence interval CI =-4.44 to -3.48; P<0.00001), HbA1c reduction of ≥0.5% (risk ratio RR=1.98; 95% CI=1.65 to 2.39; P<0.00001), and fasting plasma glucose FPG (SMD=-0.93; 95% CI=-1.77 to -0.10; P=0.03). There is no statistical difference of hypoglycemia (RR=1.09; 95% CI=0.66 to 1.79; P=0.75) or adverse events (RR=1.07; 95% CI=0.96 to 1.20; P=0.20) between two groups, but the incidence of ketone-related events is higher than those in control group (RR=0.28; 95% CI=3.96 to 11.52; P=0.01).

Conclusions: Dapagliflozin treatment benefits to reduce HbA1c and FPG for type 1 diabetes.

Keywords: Dapagliflozin; glycemic control; randomized controlled trials; type 1 diabetes.

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Figures

Figure. 1
Figure. 1
Flow diagram of study searching and selection process.
Figure. 2
Figure. 2
Forest plot for the meta-analysis of HbA1c.
Figure. 3
Figure. 3
Forest plot for the meta-analysis of HbA1c reduction of ≥0.5%.
Figure. 4
Figure. 4
Forest plot for the meta-analysis of FPG.
Figure. 5
Figure. 5
Forest plot for the meta-analysis of hypoglycemia.
Figure. 6
Figure. 6
Forest plot for the meta-analysis of ketone-related events.
Figure. 7
Figure. 7
Forest plot for the meta-analysis of adverse events.
See this image and copyright information in PMC

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