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Multicenter Study
. 2021 Mar;21(1):67-74.
doi: 10.4314/ahs.v21i1.11.

Characteristics and outcomes of patients with multiple myeloma at the Uganda Cancer Institute

Clement D Okello  1 , Yusuf Mulumba  1 , Abrahams Omoding  1 , Henry Ddungu  1 , Kristen Welch  2 , Cheryl L Thompson  2 , Andrew J Cowan  3 , Matthew M Cooney  2 , Jackson Orem  1
Affiliations
Multicenter Study

Characteristics and outcomes of patients with multiple myeloma at the Uganda Cancer Institute

Clement D Okello et al. Afr Health Sci. 2021 Mar.

Abstract

Purpose: Data on multiple myeloma (MM) in sub-Sahara Africa is scarce. In Uganda, there is a progressively increasing incidence of MM over the years.

Methods: We performed a retrospective study on 217 patients with MM at the UCI using purposive sampling method. The objectives of the study were to determine the clinical characteristics, treatment outcomes, 5 year overall survival and predictors of survival of patients with MM at the UCI from 01 January 2008 to 31 December 2012.

Results: There were 119 (54.8%) males; the mean(SD) age of the study population at presentation was 59(12.8) years; 183(84.3%) patients presented with bone pain, and 135 (61.9%) had skeletal pathology; 186(85.3%) were HIV negative, and 152(70%) had Durie-Salmon stage III. The median overall survival was 2.5 years, (95% CI, 0.393-0.595); factors significantly associated with worse survival were Durie-Salmon stage III disease, HR=5.9, 95% CI (1.61 - 21.74; P=0.007) and LDH >225 U/L HR=3.3, 95% CI (0.57 - 5.92; P=0.029).

Conclusion: Most patients with multiple myeloma at the UCI were diagnosed at a relatively young age, presented with late stage disease and bone pain, and had a shorter survival time. Factors associated with worse survival were Durie-Salmon stage III and LDH >225 U/L.

Keywords: Multiple myeloma; Uganda cancer institute.

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Figures

Figure 1
Figure 1
Kaplan-Meier Overall survival estimate
Figure 1
Figure 1
Kaplan-Meier survival estimate by stage of Multiple Myeloma
See this image and copyright information in PMC

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