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Review
. 2020 Mar 17;2(1):119-122.
doi: 10.1016/j.jaccao.2020.01.003. eCollection 2020 Mar.

Heart Failure Associated With the Epidermal Growth Factor Receptor Inhibitor Osimertinib

Andrew J Piper-Vallillo  1 , Daniel B Costa  1 , Marwa A Sabe  2 , Aarti Asnani  3
Affiliations
Review

Heart Failure Associated With the Epidermal Growth Factor Receptor Inhibitor Osimertinib

Andrew J Piper-Vallillo et al. JACC CardioOncol. .
No abstract available

Keywords: ECG, electrocardiogram; EGFR, epidermal growth factor receptor; LVEF, left ventricular ejection fraction; NRG, neuregulin; NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor; TTE, transthoracic echocardiography; cardiotoxicity; epidermal growth factor receptor; heart failure; lung cancer; osimertinib.

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Figures

Figure 1
Figure 1
Case Timeline Key clinical events are presented in chronological order outlining oncological diagnosis, timing of therapy, and development of cardiac toxicity. CMR = cardiac magnetic resonance imaging; EGFR = epidermal growth factor receptor; GDMT = guideline directed medical therapy; gen = generation; LVEF = left ventricular ejection fraction; NSCLC = non-small cell lung cancer; SOB = shortness of breath; TKI = tyrosine kinase inhibitors.
Figure 2
Figure 2
ErbB Family Receptor Signaling ErbB family receptors are stimulated by several ligands including neuregulin (NRG)-1, which leads to homo- and/or hetero-dimerization of ErbB receptors and downstream signaling to PI3-kinase—Akt and Ras—ERK. Disruption of ErbB4 heterodimerization with ErbB2 by trastuzumab impairs downstream signaling and normal cardiac myocyte stress response. Osimertinib may interfere with cardiovascular function through its affinity for the wild-type ErbB2 receptor. ATP = adenosine triphosphate.
See this image and copyright information in PMC

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