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Editorial
. 2020 Jun 16;2(2):204-206.
doi: 10.1016/j.jaccao.2020.05.006. eCollection 2020 Jun.

Cytokines Are at the Heart of It: Cytokine Release Syndrome Underlies Cardiovascular Effects of CAR T Cell

Anna B Catino  1
Affiliations
Editorial

Cytokines Are at the Heart of It: Cytokine Release Syndrome Underlies Cardiovascular Effects of CAR T Cell

Anna B Catino. JACC CardioOncol. .
No abstract available

Keywords: cardiotoxicity; chimeric antigen receptor T cell therapy; cytokine release syndrome; heart failure; leukemia; lymphoma.

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References

    1. Brown C.E., Mackall C.L. CAR T cell therapy: inroads to response and resistance. Nature Rev Immunol. 2019;19:73–74. - PubMed
    1. Park J.H., Geyer M.B., Brentjens R.J. CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date. Blood. 2016;127:3312–3320. - PMC - PubMed
    1. Ganatra S., Carver J.R., Hayek S.S. Chimeric antigen receptor T-cell therapy for cancer and heart: JACC Council Perspectives. J Am Coll Cardiol. 2019;74:3153–3163. - PMC - PubMed
    1. Ghosh A.K., Chen D.H., Guha A., Mackenzie A., Walker J.M., Roddie C. CAR T cell therapy–related cardiovascular outcomes and management. J Am Coll Cardiol CardioOnc. 2020 - PMC - PubMed
    1. Burstein D.S., Maude S., Grupp S., Griffis H., Rossano J., Lin K. Cardiac profile of chimeric antigen receptor T cell therapy in children: a single-institution experience. Biol Blood Marrow Transplant. 2018;24:1590–1595. - PubMed

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