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Review
. 2021 Jun 15;3(2):330-334.
doi: 10.1016/j.jaccao.2021.02.005. eCollection 2021 Jun.

Takotsubo Cardiomyopathy Associated With Checkpoint Inhibitor Therapy: Endomyocardial Biopsy Provides Pathological Insights to Dual Diseases

Michael Serzan  1 , Suthee Rapisuwon  1 , Jayashree Krishnan  2 , Ian C Chang  3 , Ana Barac  3
Affiliations
Review

Takotsubo Cardiomyopathy Associated With Checkpoint Inhibitor Therapy: Endomyocardial Biopsy Provides Pathological Insights to Dual Diseases

Michael Serzan et al. JACC CardioOncol. .
No abstract available

Keywords: ICI, immune checkpoint inhibitor; TTE, transthoracic echocardiogram; Takotsubo cardiomyopathy; histopathology; imaging; immune checkpoint inhibitors; immunotherapy; irAE, immune-related adverse event.

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Conflict of interest statement

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Cardiac Magnetic Resonance Imaging T2-weighted dark blood images (asterisks) show increased signal intensity in the left ventricular (LV) apical segments indicating presence of myocardial edema. LA = left atrium; RA = right atrium; RV = right ventricle.
Figure 2
Figure 2
Endomyocardial Biopsy and Chest Computed Tomography (A) Endomyocardial biopsy shows focal fibrosis without malignancy or myocarditis. Immunostaining for CD68 shows very rare macrophages (yellow arrows). (B) Chest computed tomography shows moderate consolidation in the bilateral posterior lower lobes with adjacent ground glass opacities (yellow asterisks).
See this image and copyright information in PMC

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