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- PMID: 34396570
- DOI: 10.1002/hep.32113
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Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B.Hepatology. 2021 Oct;74(4):1795-1808. doi: 10.1002/hep.31920. Epub 2021 Aug 25. Hepatology. 2021. PMID: 34037271 Free PMC article. Clinical Trial.
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Letter to the Editor: Is the HBsAg response to RO7062931 an antisense effect?Hepatology. 2022 Jan;75(1):230-231. doi: 10.1002/hep.32103. Epub 2021 Nov 27. Hepatology. 2022. PMID: 34387887 No abstract available.
References
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- Gane E, Yuen MF, Kim DJ, Chan HL, Surujbally B, Pavlovic V, et al. Clinical study of single stranded oligonucleotide RO7062931 in healthy volunteers and patients with chronic hepatitis. Hepatology. 2021 May 26. https://doi.org/10.1002/hep.31920 . [Epub ahead of print] - DOI
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- Shekhtman L, Cotler SJ, Hershkovich L, Uprichard SL, Bazinet M, Pantea V, et al. Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg. Sci Rep. 2020;10:7837.
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- Javanbakht H, Mueller H, Walther J, Zhou X, Lopez A, Pattupara T, et al. Liver‐targeted anti‐HBV single‐stranded oligonucleotides with locked nucleic acid potently reduce HBV gene expression in vivo. Mol Ther Nucleic Acids. 2018;11:441–54.
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