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Review
. 2021 Sep;50(3):369-385.
doi: 10.1016/j.ecl.2021.05.002. Epub 2021 Jul 12.

Screening for Diabetes and Prediabetes

Daisy Duan  1 , Andre P Kengne  2 , Justin B Echouffo-Tcheugui  3
Affiliations
Review

Screening for Diabetes and Prediabetes

Daisy Duan et al. Endocrinol Metab Clin North Am. 2021 Sep.

Abstract

Overt type 2 diabetes mellitus (T2DM) is preceded by prediabetes and latent diabetes (lasts 9-12 years). Key dysglycemia screening tests are fasting plasma glucose and hemoglobin A1C. Screen-detected T2DM benefits from multifactorial management of cardiovascular risk beyond glycemia. Prediabetes is best addressed by lifestyle modification, with the goal of preventing T2DM. Although there is no trial evidence of prediabetes/T2DM screening effectiveness, simulations suggest that clinic-based opportunistic screening of high-risk individuals is cost-effective. The most rigorous extant recommendations are those of the American Diabetes Association and US Preventive Services Task Force, which advise opportunistic 3-yearly screening.

Keywords: Cost-effectiveness; Diabetes; Effectiveness; Prediabetes; Screening.

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Conflict of interest statement

Disclosure The authors have no conflict of interest related to this article. Dr J.B. Echouffo-Tcheugui was supported by NIH/NHLBI grant K23 HL153774. Dr D. Duan was supported by NIH/NHLBI grant 5T32HL110952.

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