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Comment
. 2021 Aug 16;6(1):302.
doi: 10.1038/s41392-021-00720-2.

Cyro-EM structure of human mGlus: leading therapeutic potential to neurological diseases

Huan Xiao  1 , Qiu Sun  2
Affiliations
Comment

Cyro-EM structure of human mGlus: leading therapeutic potential to neurological diseases

Huan Xiao et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Conformational changes of mGlu2. a Cryo-EM structures of the inactive mGlu2, Gi-free agonist-bound mGlu2, and fully active mGlu2–Gi. b Dimerization modes of mGlu2 TMD from inactivation to activation
See this image and copyright information in PMC

Comment on

  • Structures of human mGlu2 and mGlu7 homo- and heterodimers.
    Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q. Du J, et al. Nature. 2021 Jun;594(7864):589-593. doi: 10.1038/s41586-021-03641-w. Epub 2021 Jun 16. Nature. 2021. PMID: 34135509
  • Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4.
    Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B. Lin S, et al. Nature. 2021 Jun;594(7864):583-588. doi: 10.1038/s41586-021-03495-2. Epub 2021 Jun 16. Nature. 2021. PMID: 34135510

References

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