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. 2021 Sep:69:102673.
doi: 10.1016/j.amsu.2021.102673. Epub 2021 Aug 12.

Association of serum KL-6 levels on COVID-19 severity: A cross-sectional study design with purposive sampling

Titah Dhadhari Suryananda  1 , Resti Yudhawati  1
Affiliations

Association of serum KL-6 levels on COVID-19 severity: A cross-sectional study design with purposive sampling

Titah Dhadhari Suryananda et al. Ann Med Surg (Lond). 2021 Sep.

Abstract

Background: The main target of SARS-CoV2 is the alveolar type II (AT2) cells of the lung. SARS-CoV2 evades the innate immune system resulting in the release of proinflammatory cytokines (IL-1β, IL-6, TNF-α) which causes AT2 cell damage. Krebs von den Lungen (KL-6) is a specific biomarker of AT2 cell damage. KL-6 is produced in AT2 cells that are injured/regenerated.

Objective: Research that discusses the role of KL-6 in COVID-19 is still being debated and not much has been done in Indonesia.

Methods: This study was an analytical study with a prospective design on 75 COVID-19 patients who were treated. Subjects were divided into two large groups according to their degree of severity, 57 subjects with severe degrees and 18 subjects with non-severe degrees. The serum KL-6 levels were measured on days 0 and 6. Data were analyzed using paired t-test and independent t-test for data were normally distributed and Wilcoxon test and Mann Whitney test for data that were not normally distributed.

Result: In this study, the mean serum KL-6 for day 0 in the severe group was higher than the non-severe group with values of 45.70 U/mL and 44.85 U/mL. On day 6, the mean serum KL-6 in the severe group was lower than that in the non-severe group with values of 41.3 U/mL and 41.95 U/mL. Serum KL-6 in the severe group experienced an even greater decrease than the non-severe group.

Conclusion: There was no significant association between serum KL-6 values on 0 days in the severity of COVID-19.

Keywords: AT2; COVID-19; KL-6.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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