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. 2021 Jun 28;6(4):852-856.
doi: 10.1002/lio2.608. eCollection 2021 Aug.

Cisplatin ototoxicity histopathology

Sarah E Hodge  1 , Ivan A Lopez  2 , Gail Ishiyama  3 , Akira Ishiyama  2
Affiliations

Cisplatin ototoxicity histopathology

Sarah E Hodge et al. Laryngoscope Investig Otolaryngol. .

Abstract

This study investigates the histopathological changes of the cochlea and vestibular end organs of a patient who received cisplatin for Hodgkin's lymphoma. He experienced acute high-frequency sensorineural hearing loss and tinnitus after receiving treatment. Using histopathological analysis of his temporal bones after he unfortunately succumbed to his disease, we found that the ototoxic effect of cisplatin is primarily within the cochlea, with significant damage located at the organ of Corti at the base-hook region, consistent with findings in animal models. The effects of cisplatin were minimal when reviewing the vestibular end organs.

Keywords: cisplatin; ototoxicity; temporal bone; vestibular end organs.

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Conflict of interest statement

The authors declare no conflict of interest to report.

Figures

FIGURE 1
FIGURE 1
A, Audiogram before cisplatin treatment; B, audiogram after treatment; B1, cytocochleogram from the temporal bone after cisplatin; C, cytocochleogram performed on a healthy cochlea of a 30‐year‐old male with normal hearing
FIGURE 2
FIGURE 2
A, Mid‐modiolus section of the right side temporal bone (×100 magnification); B, organ of Corti at the basal turn; C, organ of Corti at the apex; D, organ of Corti at mid‐basal turn; E, stria vascularis; F, spiral ganglion cells at the basal region (×200). Hematoxylin and eosin stain (H&E) staining
FIGURE 3
FIGURE 3
Vestibular endorgans of the right side temporal bone. A, Lateral crista; B, anterior crista; C, posterior crista; D, saccule; E, utricle. A1‐E1 shows high‐magnification view of the vestibular sensory epithelium; hair cells (hc) are very well preserved. ×100 magnification, A‐E; ×400, A1‐E1
See this image and copyright information in PMC

References

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