Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug 11;4(3):e354.
doi: 10.1002/hsr2.354. eCollection 2021 Sep.

Comparison of platelet-rich fibrin with zinc oxide eugenol in the relief of pain in alveolar osteitis

Satheesh Reeshma  1 , Chacko Pearl Dain  1
Affiliations

Comparison of platelet-rich fibrin with zinc oxide eugenol in the relief of pain in alveolar osteitis

Satheesh Reeshma et al. Health Sci Rep. .

Abstract

Background and aims: Alveolar osteitis (AO) is the most common painful post-operative complication after tooth extraction. The common modalities used in the management of AO are lavage, placement of medicated dressings, analgesics, and antibiotics. The present study was undertaken to compare platelet-rich fibrin (PRF) and zinc oxide eugenol (ZOE) for pain relief in AO.

Methods: All cases meeting the eligibility criteria received two different treatment modalities over a span of 18 months. At the analysis stage, the final sample size comprised 70 patients, with 35 patients appropriated in each group. Group A patients received ZOE and Group B received PRF. Pain scores were measured on "1st, 3rd, 5th, and 7th" days based on a visual analogue scale (VAS) and compared in both groups of patients. The collected data were analyzed using the chi-square test, t test, and Mann-Whitney U test.

Results: In patients treated with ZOE dressing, the average VAS scores observed were 7.4 ± 1.5, 5.1 ± 1.1, 3.4 ± 0.9, and 2.1 ± 0.7, respectively, on the "1st, 3rd, 5th, and 7th" follow-up days. In patients treated with PRF, the average VAS score observed were 4.1 ± 1.2, 2.6 ± 0.9, 1.7 ± 0.9, and 0.8 ± 0.8 respectively.

Conclusion: Both ZOE and PRF were effective in pain control during the follow-up period. However, the pain intensity measured as a pain score using VAS was, lower in the PRF group than in the ZOE group on all follow-up days.

Keywords: VAS; alveolar osteitis; pain relief; platelet rich fibrin; zinc oxide eugenol.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Flow chart showing the phases of prospective comparative study
FIGURE 2
FIGURE 2
(A) Centrifuge used for platelet‐rich fibrin extraction (Remi clinical centrifuge C‐854/4, Remi Elektrotechnik Limited, India). (B) Blood after centrifugation. (C) Platelet‐rich fibrin. (D) Platelet‐rich fibrin placed inside the socket. (E) Platelet‐rich fibrin‐treated wound on 7th postoperative day
FIGURE 3
FIGURE 3
Bar diagram showing percentage distribution of the mean value of pain score between treatment groups on (A) Day 1, (B) Day 3, (C) Day 5, and (D) Day 7
See this image and copyright information in PMC

References

    1. Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309‐317. - PubMed
    1. Kolokythas A, Olech E, Miloro M. Alveolar osteitis: a comprehensive review of concepts and controversies. Int J Dent. 2010;2010:249073. - PMC - PubMed
    1. Faizel S, Thomas S, Yuvaraj V, et al. Comparision between neocone, alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. J Maxillofac Oral Surg. 2015;14(2):312‐320. - PMC - PubMed
    1. Birn H. Etiology and pathogenesis of fibrinolytic alveolitis (“dry socket”). Int J Oral Sug. 1973;2:211‐263.
    1. Nitzan DW. On the genesis of ‘dry socket’. J Oral Maxillofac Surg. 1983;41:706‐710. - PubMed

LinkOut - more resources