Statins in mature B-cell lymphomas and leukaemias

Liam Smyth^{1

2}, Danielle N Blunt³, Matthew C Cheung^{4

5}

Affiliations

¹ Department of Haematology, St Vincent's University Hospital, Dublin, Ireland.
² UCD School of Medicine, University College Dublin, Dublin, Ireland.
³ Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia.
⁴ Odette Cancer Centre, Sunnybroook Health Sciences Centre, Toronto, ON, Canada.
⁵ Division of Hematology/Medical Oncology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Comment

Liam Smyth et al. Br J Haematol. 2021 Nov.

. 2021 Nov;195(4):490-492.

doi: 10.1111/bjh.17778. Epub 2021 Aug 16.

Liam Smyth^{1

2}, Danielle N Blunt³, Matthew C Cheung^{4

5}

¹ Department of Haematology, St Vincent's University Hospital, Dublin, Ireland.
² UCD School of Medicine, University College Dublin, Dublin, Ireland.
³ Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia.
⁴ Odette Cancer Centre, Sunnybroook Health Sciences Centre, Toronto, ON, Canada.
⁵ Division of Hematology/Medical Oncology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

No abstract available

Comment on

Statin use and survival in 16 098 patients with non-Hodgkin lymphoma or chronic lymphocytic leukaemia treated in the rituximab era.
Brånvall E, Ekberg S, Eloranta S, Wästerlid T, Birmann BM, Smedby KE. Brånvall E, et al. Br J Haematol. 2021 Nov;195(4):552-560. doi: 10.1111/bjh.17733. Epub 2021 Jul 31. Br J Haematol. 2021. PMID: 34331461

1. Ageberg M, Rydstrom K, Linden O, Linderoth J, Jerkeman M, Drott K. Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines. Exp Cell Res. 2011;317(8):1179-91.
1. Ye X, Mneina A, Johnston JB, Mahmud SM. Associations between statin use and non-Hodgkin lymphoma (NHL) risk and survival: a meta-analysis. Hematol Oncol. 2017;35(2):206-14.
1. Desai P, Wallace R, Anderson ML, Howard BV, Ray RM, Wu C, et al. An analysis of the association between statin use and risk of endometrial and ovarian cancers in the Women's Health Initiative. Gynecol Oncol. 2018;148(3):540-6.
1. Ajith TA, Harikumar KB, Thasna H, Sabu MC, Babitha NV. Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice. Clin Chim Acta. 2006;366(1-2):322-8.
1. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. The interplay between cell signalling and the mevalonate pathway in cancer. Nat Rev Cancer. 2016;16(11):718-31.