Hit Early and Hit Hard in Pulmonary Arterial Hypertension? Not So Fast!
- PMID: 34402772
- PMCID: PMC8528528
- DOI: 10.1164/rccm.202107-1570ED
Hit Early and Hit Hard in Pulmonary Arterial Hypertension? Not So Fast!
Comment on
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Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension.Am J Respir Crit Care Med. 2021 Oct 1;204(7):842-854. doi: 10.1164/rccm.202009-3698OC. Am J Respir Crit Care Med. 2021. PMID: 34185620
References
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- Rich S, Kaufmann E, Levy PS. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med. 1992;327:76–81. - PubMed
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- Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, et al. AMBITION Investigators. Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension. N Engl J Med. 2015;373:834–844. - PubMed
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- Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA, et al. SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013;369:809–818. - PubMed
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- Chin KM, Sitbon O, Doelberg M, Gibbs JSR, Hoeper MM, Martin N, et al. Efficacy and safety of initial triple oral versus initial double oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension (PAH): results of the randomized controlled TRITON study. Am J Respir Crit Care Med. 2020;201:A2928.
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