A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review

Marziyeh Najafi¹, Omid Nikpayam², Omid Mohammad Tavakoli-Rouzbehani³, Shahab Papi⁴, Atefeh Amrollahi Bioky⁵, Elham Sadat Ahmadiani⁵, Golbon Sohrab⁶

Affiliations

¹ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: m.najafi284@gmail.comi.
² Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Nikpayamomid@gmail.com.
³ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Public Health, Faculty of Health, Social Determinants of Health Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
⁵ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: golbonsohrab@yahoo.com.

PMID: 34403949
DOI: 10.1016/j.dsx.2021.102224

A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review

Marziyeh Najafi et al. Diabetes Metab Syndr. 2021 Sep-Oct.

. 2021 Sep-Oct;15(5):102224.

doi: 10.1016/j.dsx.2021.102224. Epub 2021 Jul 18.

Authors

Marziyeh Najafi¹, Omid Nikpayam², Omid Mohammad Tavakoli-Rouzbehani³, Shahab Papi⁴, Atefeh Amrollahi Bioky⁵, Elham Sadat Ahmadiani⁵, Golbon Sohrab⁶

Affiliations

¹ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: m.najafi284@gmail.comi.
² Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Nikpayamomid@gmail.com.
³ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Public Health, Faculty of Health, Social Determinants of Health Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
⁵ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: golbonsohrab@yahoo.com.

PMID: 34403949
DOI: 10.1016/j.dsx.2021.102224

Abstract

Background and aims: Silent information regulator 1 (Sirt1) involved in histone stability, transcriptional activity, and translocation. This systematic review aimed to summarize the effects of Resveratrol on Sirt1 expression.

Materials and methods: Electronic databases including Scopus, Medline and web of knowledge were searched up to March 2020.

Results: Out of 801 studies identified in our search finally 12 articles included. Totally six studies evaluated the effects of resveratrol on SIRT1 gene expression, and six articles investigate protein expression.

Conclusion: The results of the included studies showed that resveratrol supplementation had beneficial effects on protein and gene expression of SIRT1.

Keywords: Resveratrol; SIRT-1; Sirtuins; Supplementation; Systematic review.

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Conflict of interest statement

Declaration of competing interest The authors had no conflict of interest.

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A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review

Affiliations

A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical