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. 2022 Jun;29(3):255-265.
doi: 10.1007/s12529-021-10016-y. Epub 2021 Aug 17.

The Nocebo Effect: A Review of Contemporary Experimental Research

Branka Bagarić  1 , Nataša Jokić-Begić  2 , Claire Sangster Jokić  3
Affiliations

The Nocebo Effect: A Review of Contemporary Experimental Research

Branka Bagarić et al. Int J Behav Med. 2022 Jun.

Abstract

Background: Nocebo effect, the occurrence of adverse symptoms fallowing an inactive treatment, is much less understood than its opposite, placebo effect. This systematic review of contemporary studies exploring the nocebo effect focuses on (1) the mechanisms underlying the nocebo effect, (2) the characteristics of participants exhibiting a more intensive nocebo response, and (3) the circumstances that might reduce or prevent the nocebo effect.

Method: We included experimental nocebo studies published in English that examined the occurrence of nocebo in various domains (i.e., types of sensations and symptoms) and different levels of nocebo response (e.g., performance, self-assessment) and in different populations of participants (healthy and clinical). Using Web of Science, PsycInfo and PubMed, we identified 25 papers (35 studies) that met our criteria with a total of N = 2614 participants, mostly healthy volunteers.

Results: Nocebo was invoked by manipulating expectations, conditioning or both. A narrative content synthesis was conducted. Nocebo was successfully invoked in a range of domains (e.g., pain, nausea, itch, skin dryness) and levels (sensory, affective, psychological, and behavioral). Various characteristics of the conditioning procedure and participants' emotions, expectations, and dispositions are found to be related to the nocebo response, which sheds insight into the possible mechanisms of the nocebo effect. Strategies successful and unsuccessful in diminishing the nocebo response are identified. Limitations of this review include a small sample of studies.

Conclusion: These findings point to the universality of nocebo as well as to the importance of participant characteristics and experimental circumstances in invoking the nocebo effect. Further research should examine the nocebo effect in clinical populations.

Keywords: Nocebo; Nocebo mechanisms; Nocebo risk factors; Reducing and preventing nocebo; Systematic review.

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