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Case Reports

. 2022 Jan;196(1):e11-e14.

doi: 10.1111/bjh.17782. Epub 2021 Aug 17.

Thrombotic thrombocytopenic purpura temporally associated with BNT162b2 vaccination in an adolescent successfully treated with caplacizumab

Amrit Kirpalani^{1

2}, Justin Garabon¹, Kiersten Amos¹, Serina Patel^{1

2}, Ajay P Sharma^{1

2}, Saptharishi Lalgudi Ganesan^{1

2}, Michelle Barton^{1

2}, Chantel Cacciotti^{1

2}, Sarah Leppington³, Linda Bakovic^{4

5}, Shih-Han Susan Huang^{2

6}, Michael J Knauer⁷, Soumitra Tole^{1

2}

Affiliations

Affiliations

¹ Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
² Department of Pediatrics, London Health Sciences Centre, London, ON, Canada.
³ Children's Hospital, London Health Sciences Centre, London, ON, Canada.
⁴ Department of Pediatrics, Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
⁵ Department of Pediatrics, Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada.
⁶ Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
⁷ Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

PMID: 34405400
PMCID: PMC8444813
DOI: 10.1111/bjh.17782

Case Reports

Thrombotic thrombocytopenic purpura temporally associated with BNT162b2 vaccination in an adolescent successfully treated with caplacizumab

Amrit Kirpalani et al. Br J Haematol. 2022 Jan.

. 2022 Jan;196(1):e11-e14.

doi: 10.1111/bjh.17782. Epub 2021 Aug 17.

Authors

Amrit Kirpalani^{1

2}, Justin Garabon¹, Kiersten Amos¹, Serina Patel^{1

2}, Ajay P Sharma^{1

2}, Saptharishi Lalgudi Ganesan^{1

2}, Michelle Barton^{1

2}, Chantel Cacciotti^{1

2}, Sarah Leppington³, Linda Bakovic^{4

5}, Shih-Han Susan Huang^{2

6}, Michael J Knauer⁷, Soumitra Tole^{1

2}

Affiliations

¹ Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
² Department of Pediatrics, London Health Sciences Centre, London, ON, Canada.
³ Children's Hospital, London Health Sciences Centre, London, ON, Canada.
⁴ Department of Pediatrics, Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
⁵ Department of Pediatrics, Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada.
⁶ Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
⁷ Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

PMID: 34405400
PMCID: PMC8444813
DOI: 10.1111/bjh.17782

No abstract available

Keywords: COVID-19; TTP; adolescent; caplacizumab; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Fig 1 — Fig 1
Platelet count over the course of therapy. Oral prednisone and daily therapeutic plasma exchange (TPE) were started upon admission. The patient had an exacerbation within 24 h of holding TPE to administer rituximab. She received a pulse of methylprednisolone and caplacizumab was administered on Day 9.

See this image and copyright information in PMC

References

1. Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836–46. - PubMed
1. Scully M, Cataland SR, Peyvandi F, Coppo P, Knobl P, Kremer Hovinga JA, et al. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019;380(4):335–46. - PubMed
1. Joly BS, Coppo P, Veyradier A. Pediatric thrombotic thrombocytopenic purpura. Eur J Haematol. 2018;101(4):425–34. - PubMed
1. Siddiqui A, Journeycake JM, Borogovac A, George JN . Recognizing and managing hereditary and acquired thrombotic thrombocytopenic purpura in infants and children. Pediatr Blood Cancer. 2021;68(5):e28949. - PubMed
1. Dias PJ, Gopal S. Refractory thrombotic thrombocytopenic purpura following influenza vaccination. Anaesthesia. 2009;64(4):444–6. - PubMed

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