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. 2021 Aug 16:63:e65.
doi: 10.1590/S1678-9946202163065. eCollection 2021.

Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis

Marina Pires Nishi  1 , Eliane Viana Mancuzo  2   3 , Nara Sulmonett  3 , Isabela Neves de Almeida  4   5 , Aina Liz Alves César  4 , Silvana Spindola de Miranda  2   4
Affiliations

Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis

Marina Pires Nishi et al. Rev Inst Med Trop Sao Paulo. .

Abstract

Even when treated adequately, pulmonary tuberculosis can lead to pulmonary sequelae. Patients treated for PTB between 2012 and 2016 answered a standardized questionnaire and underwent chest radiography and spirometry, measurement of absolute pulmonary volume, Diffusing Capacity for Carbon Monoxide (DLCO) and the 6-min walk test (6MWT) on two occasions: within the first year after the end of treatment (follow-up 1), and one and two years after follow-up 1 (follow-up 2). A total of 55 patients they underwent spirometry, 23 (41.82%) had obstructive ventilatory disorder (OVD) and eight (14.5%) had moderate OVD. In total, 29 patients underwent pulmonary function tests (PFTs) and 24 patients underwent the 6MWT on two occasions. The functional changes after PTB treatment appear not to have varied between one and two years of follow-up. There was a correlation between low FEV1 and low DLCO (p<0.001); low DLCO and low 6MWT (p<0.001) and radiographic abnormalities and low FEV1 (p=0.033). The most frequently observed change in spirometry was found in patients with OVD.

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Conflict of interest statement

CONFLICT OF INTERESTS

The authors declare there is no conflict of interests.

Figures

Figure 1
Figure 1. Flowchart of the participants’ eligibility and their inclusion in the study. *2 patients did not meet all inclusion criteria of spirometry; **19 participants did not have pulmonary volume measurements and DLco in follow-up 1 due to technical problems with the equipment; #9 Participants did not have 6MWT in follow-up 1; 2 for disability due rheumatoid arthritis and 7 for absence on the day of the exam; ***7 participants did not have PFTs during follow-up 2 due to technical problems with the equipment; ##22 participants did not have 6MWT during follow-up 2, 15 due to lack of medical request for the exam and 7 for absence on the day of the exam.
Supplementary Figure S1
Supplementary Figure S1. – Change of lung function variables between the follow-up 1 and 2. a) FVC in liters and %; b) FEV1 in liters and % c) 6MWTD in meters and %; FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 second; 6MWTD = 6-min walk test distance; L = liters, % = predicted percentual.
Supplementary Figure S2
Supplementary Figure S2. Analysis between FEV1 (liters) and Chest X-ray, during follow-up 1.
Supplementary Figure S3
Supplementary Figure S3. Correlation between FEV1 (liters) and DLCO (mL min-1 mmHg-1) during follow-up 1. DLCO = diffusing capacity for carbon monoxide; FEV1 = forced expiratory volume in 1 second.
Supplementary Figure S4
Supplementary Figure S4. Correlation between FEV1 (liters) and 6MWTD (meters) during follow-up 1.
Supplementary Figure S5
Supplementary Figure S5. Correlation between DLCO (mL min-1 mmHg-1) and 6MWTD (meters) during follow-up 1.
See this image and copyright information in PMC

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