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. 2021 Aug 18;11(8):e048115.
doi: 10.1136/bmjopen-2020-048115.

Feasibility and potential effects of tai chi for the fatigue-sleep disturbance-depression symptom cluster in patients with breast cancer: protocol of a preliminary randomised controlled trial

Li-Qun Yao  1 , Jing-Yu Benjamin Tan  2 , Catherine Turner  1 , Tao Wang  1
Affiliations

Feasibility and potential effects of tai chi for the fatigue-sleep disturbance-depression symptom cluster in patients with breast cancer: protocol of a preliminary randomised controlled trial

Li-Qun Yao et al. BMJ Open. .

Abstract

Introduction: The fatigue-sleep disturbance-depression symptom cluster (FSDSC) is one of the most common and debilitating side effects in patients with breast cancer (BC) throughout their treatment trajectory. Tai chi has been supported as a promising non-pharmacological intervention for the individual symptom relief of cancer-related fatigue, sleep disturbance and depression. However, relevant evidence of using tai chi for FSDSC management in patients with BC has been lacking.

Methods: This study will be a two-arm, single-blinded pilot randomised controlled trial involving an 8-week intervention and a 4-week follow-up. Seventy-two patients with BC experiencing the FSDSC will be recruited from two tertiary medical centres in China. The participants will be randomised to either a tai chi group (n=36) or a control group (n=36). The participants in the tai chi group will receive an 8-week tai chi intervention in addition to standard care, while the participants in the control group will receive standard care only consisting of a booklet on the self-management of cancer symptoms. The primary outcomes will include a series of feasibility assessments of the study protocol in relation to the study's methodological procedures, including subject recruitment and follow-up process, completion of study questionnaires and the feasibility, acceptability and safety of the intervention. The secondary outcomes will be the clinical outcomes regarding the effects of tai chi on the FSDSC and quality of life, which will be evaluated by the Brief Fatigue Inventory, the Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale and the Functional Assessment of Cancer Therapy-Breast questionnaires.

Ethics and dissemination: Ethics approval was obtained from relevant sites (H19094, KY2019133, 201932). The findings of the study will be published in peer-reviewed scientific journals and at conferences.

Trail registration number: NCT04190342; Pre-results.

Keywords: breast tumours; clinical trials; complementary medicine.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
CONSORT flow chart of the study. BC, breast cancer; CONSORT, Consolidated Standards of Reporting Trials; FSDSC, fatigue-sleep disturbance-depression symptom cluster.
See this image and copyright information in PMC

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References

    1. Malvezzi M, Carioli G, Bertuccio P, et al. . European cancer mortality predictions for the year 2019 with focus on breast cancer. Ann Oncol 2019;30:781–7. 10.1093/annonc/mdz051 - DOI - PubMed
    1. Jain S, Boyd C, Fiorentino L, et al. . Are there efficacious treatments for treating the fatigue-sleep disturbance-depression symptom cluster in breast cancer patients? a rapid evidence assessment of the literature (REAL(©)). Breast Cancer 2015;7:267–91. 10.2147/BCTT.S25014 - DOI - PMC - PubMed
    1. Hsu H-T, Lin K-C, Wu L-M, et al. . Symptom cluster trajectories during chemotherapy in breast cancer outpatients. J Pain Symptom Manage 2017;53:1017–25. 10.1016/j.jpainsymman.2016.12.354 - DOI - PubMed
    1. Liu L, Rissling M, Natarajan L, et al. . The longitudinal relationship between fatigue and sleep in breast cancer patients undergoing chemotherapy. Sleep 2012;35:237–45. 10.5665/sleep.1630 - DOI - PMC - PubMed
    1. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 2001;28:465–70. - PubMed

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