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Case Reports
. 2021 Sep;20(3):464-469.
doi: 10.1007/s12663-020-01447-3. Epub 2020 Sep 26.

Tongue Spindle Cell Rhabdomyosarcoma: A Rare Case Report and Literature Review

Ursula M Jariod-Ferrer  1 , Miguel Angel Trigo-Cebrian  2 , Bianca Pantilie  1 , María V Simon Sanz  1 , Leire Esparza Lasaga  1 , Marina A Gavin-Clavero  1 , Elena Delso-Gil  1 , Javier Martinez-Trufero  3
Affiliations
Case Reports

Tongue Spindle Cell Rhabdomyosarcoma: A Rare Case Report and Literature Review

Ursula M Jariod-Ferrer et al. J Maxillofac Oral Surg. 2021 Sep.

Abstract

Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm with its origin in the skeletal muscle and is extremely rare in adults. By the World Health Organization (WHO), a new variant of RMS has been classified, i.e. the spindle cell (Sc) and sclerosing (S) RMS. While the Sc-RMS shows intersecting fascicles of nonpleomorphic spindle cells, the S-RMS is characterized by a marked hyalinization in a pseudovascular growth pattern associated with round-to-spindled tumour cells. According to the analysed data, the Sc/S-RMS variant has a worse outcome than other variants. The new classification of the Sc/S-RMS variant is valuable to the clinical practice. There are not many oral Sc/S-RMS cases reported. The aim of this paper is to demonstrate that an early diagnosis, an adequate treatment and a multidisciplinary approach have a positive effect on the prognosis of the patient. In this study, we analyse a new case of Sc-RMS variant in a young adult with an early diagnosis and a favourable outcome as a result of an appropriated multidisciplinary treatment: early surgery, radiotherapy and chemotherapy treatment.

Keywords: Oral cancer; Rhabdomyosarcoma; Sarcoma; Spindle cell rhabdomyosarcoma.

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Conflict of interest statement

Conflict of interestThere is no conflict of interest in the present paper.

Figures

Fig. 1
Fig. 1
Extracapsular biopsy of the tumour
Fig. 2
Fig. 2
Spindle cell varaint RMS. a Spindly sarcomatous cells disposed in fascicles. Hematoxilina and Eosina (H and E) × 10. b Sarcomatous cells with rhabdomyoblastic cells. H and E × 20. c Diffuse desmin positivity ×  10. d Diffuse MyoD1 positivity. DAB ×  20
Fig. 3
Fig. 3
Two months after surgery patient image. The patient hasn’t sequels after surgery
Fig. 4
Fig. 4
Forty eight months after the surgery. The patient is disease-free
See this image and copyright information in PMC

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