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Review
. 2021 Aug 12:17:823-830.
doi: 10.2147/TCRM.S275076. eCollection 2021.

The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence

Manasvi Gupta  1 , Shiavax Rao  2 , Gaurav Manek  1 , Gregg C Fonarow  3 , Raktim K Ghosh  4
Affiliations
Review

The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence

Manasvi Gupta et al. Ther Clin Risk Manag. .

Abstract

The burden and cost of heart failure management, primarily in the form of hospitalization in the setting of decompensated heart failure, continue to be some of the biggest clinical challenges in cardiovascular medicine. In recently published randomized controlled trials, including DAPA-HF, sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin was shown to reduce hospitalization from heart failure or mortality associated with cardiovascular causes, when added to existing guideline-directed medical therapy. The American College of Cardiology (ACC) released a Clinical Pathway guideline that recommends the use of dapagliflozin in clinical management of heart failure, with or without diabetes. Furthermore, the results of the DAPA-CKD trial broaden the utility of dapagliflozin as a therapeutic option in patients with advanced kidney disease. In this article, the authors explore the existing evidence on dapagliflozin in heart failure with reduced ejection fraction and highlight the need for further research on uses of dapagliflozin in the world of heart failure.

Keywords: DAPA-CKD; DAPA-HF; DECLARE-TIMI; DEFINE-HF; HFrEF; dapagliflozin.

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Conflict of interest statement

Dr Fonarow’s disclosures include consulting for Abbott, Amgen, AstraZeneca, Bayer, Edwards, Janssen, Medtronic, Merck, and Novartis. The authors reported no other potential conflicts of interest for this work.

Figures

Figure 1
Figure 1
Chronology of key trials evaluating dapagliflozin.
See this image and copyright information in PMC

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